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Perceptual Deficits in Schizophrenia

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ClinicalTrials.gov Identifier: NCT02337439
Recruitment Status : Active, not recruiting
First Posted : January 13, 2015
Last Update Posted : November 7, 2017
Sponsor:
Collaborator:
Brain & Behavior Research Foundation
Information provided by (Responsible Party):
VA Connecticut Healthcare System

Brief Summary:

In this study, participants with schizophrenia and schizoaffective are given computer exercises to complete. The goals of the study are to determine whether: 1) any of the computer exercises can improve information processing problems in schizophrenia, 2) improvements in information processing are related to other cognitive improvements, and 3) there are changes in brain activity associated with using the computer exercises.

The study will involve clinical interviews, cognitive tests, and frequent computerized cognitive training over the course of 2 months. Some participants will also have electroencephalography, a non-invasive test that measures brain activity, to determine whether there are changes in brain activity with the computer training.


Condition or disease Intervention/treatment Phase
Schizophrenia Schizoaffective Disorder Behavioral: Sensory Information Processing Training Behavioral: Active Control Training Not Applicable

Detailed Description:

Schizophrenia is a disabling neurodevelopmental illness, affecting nearly 1% of the population. The disability of schizophrenia is due in large part to the effects of the illness on cognitive faculties. Current medications for schizophrenia do not generally improve cognition, so a major contribution to disability remains undertreated. Computerized cognitive remediation programs, which produce activity-dependent recruitment of neural resources to specifically enhance under-functioning brain systems, have been effective at improving both cognition and community functioning in patients with schizophrenia, but the effects are still modest. Our preliminary work has suggested that our training is associated with improvements in visual memory, though visual memory has been a cognitive area more refractory to cognitive training.

In this study, participants with schizophrenia or schizoaffective disorder will be randomized to receive different computer exercises to help determine whether computer exercises can improve memory in schizophrenia, and whether the cognitive training is associated with changes in neural activity.


Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Cognitive Remediation for Perceptual Deficits in Schizophrenia
Study Start Date : August 2014
Estimated Primary Completion Date : January 2018
Estimated Study Completion Date : December 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Schizophrenia

Arm Intervention/treatment
Experimental: Sensory Information Processing Training
Computerized training designed to improve sensory processing
Behavioral: Sensory Information Processing Training
Computer exercises requiring identification of visual stimuli on computer screen and response with keyboard

Active Comparator: Active Control Training
Commercially available computer exercises that were not designed specifically to improve sensory information processing.
Behavioral: Active Control Training
Commercially available educational software




Primary Outcome Measures :
  1. Cognitive test performance [ Time Frame: up to 6 months ]
    Neuropsychological testing


Secondary Outcome Measures :
  1. Psychiatric symptoms [ Time Frame: up to 6 months ]
    Clinical interviews and ratings

  2. Social Functioning [ Time Frame: up to 6 months ]
    Clinical rating scales



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • schizophrenia or schizoaffective disorder
  • English speaking and reading

Exclusion Criteria:

  • current substance abuse
  • visual impairment
  • neurological conditions
  • current enrollment in another research study

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02337439


Locations
United States, Connecticut
Yale University School of Medicine
New Haven, Connecticut, United States, 06511
Sponsors and Collaborators
VA Connecticut Healthcare System
Brain & Behavior Research Foundation

Publications:
Responsible Party: VA Connecticut Healthcare System
ClinicalTrials.gov Identifier: NCT02337439     History of Changes
Other Study ID Numbers: V1CDA2013-24
01856 ( Other Identifier: VACHS IRB )
First Posted: January 13, 2015    Key Record Dates
Last Update Posted: November 7, 2017
Last Verified: November 2017

Additional relevant MeSH terms:
Schizophrenia
Psychotic Disorders
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders