Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02327533|
Recruitment Status : Completed
First Posted : December 30, 2014
Last Update Posted : December 30, 2014
|Condition or disease|
|Generalized Aggressive Periodontitis|
Aggressive periodontitis (AgP) is an inflammatory periodontal disease which is complex, multifactorial, and destructive. Progression and severity of the disease depend on interacting risk factors such as: immunological, microbiological, environmental, and genetic factors, as well as age, sex, and race.Some patients are genetically predisposed to AgP; they have immunological abnormalities, which are thought to be under genetic control. However, high susceptibility for periodontal destruction and the relationship between inflammatory changes, and genetic factors remain unclear.
Gene expression profiling is a powerful means of generating comprehensive genome-level data sets on diseases such as cancer, asthma, rheumatoid disorders and periodontitis, and provides significant insight information for these diseases. Gene expression profiling may provide an evidence for involving genes in the pathogenesis of AgP and generate further information other than clinical signs and symptoms of AgP.
The aim of this study was to identify gene-expression patterns of patients with generalized aggressive periodontitis by whole-transcriptome gene-expression analyses.
|Study Type :||Observational|
|Actual Enrollment :||60 participants|
|Official Title:||Gene Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-based Microarray Analysis|
|Study Start Date :||February 2013|
|Actual Primary Completion Date :||September 2014|
|Actual Study Completion Date :||December 2014|
Patients with Aggressive Periodontitis
The periodontal diagnosis of subjects with GAgP was established on the basis of clinical and radiographic criteria and was defined by the 1999 International World Workshop for a Classification of Periodontal Diseases and Conditions.(Lang et al., 1999)
Control subjects had no radiographic evidence of bone loss or any sign of past and present periodontitis.
- mRNA quantification [ Time Frame: 2 months ]
- Definition of gen networking and new molecular pathways [ Time Frame: 2 months ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02327533
|Principal Investigator:||Esra Güzeldemir-Akçakanat, DDS, PhD||Kocaeli University|