"Exhaled Breath Condensate" in Allogeneic Stem Cell Recipients and the Value in Follow-up
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ClinicalTrials.gov Identifier: NCT02318316 |
Recruitment Status : Unknown
Verified December 2014 by Nilgün Yılmaz Demirci, Gazi University.
Recruitment status was: Not yet recruiting
First Posted : December 17, 2014
Last Update Posted : December 17, 2014
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Condition or disease | Intervention/treatment |
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Exhaled Breath Condensate | Other: Exhaled breath condensate |
Study Type : | Observational |
Estimated Enrollment : | 80 participants |
Observational Model: | Case-Only |
Time Perspective: | Prospective |
Official Title: | "Exhaled Breath Condensate" in Allogeneic Stem Cell Recipients and Value in Follow-up |
Study Start Date : | December 2014 |
Estimated Primary Completion Date : | December 2015 |
Estimated Study Completion Date : | April 2016 |
Group/Cohort | Intervention/treatment |
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EBC level
Exhaled breath condensate level of allogeneic stem cell transplantation patients
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Other: Exhaled breath condensate
Breath condensate samples will be collected with a commercially available condenser (EcoScreen®, Erich Jaeger, Germany). Subjects will breathe through a mouthpiece and a two-way non-rebreathing value in which inspiratory and expiratory air were separated, and saliva was trapped. They will be asked to breathe at a normal frequency and tidal volume for 15 minutes while wearing nose clips, allowing collection of 1.5-2.5 mL of condensate. After collecting this, pH will be measured and the waste collection will be stored at -80 degrees. Then 8 isoprostane and nitrotyrosine will be measured collectively |
- The pH level of exhaled breath condansate [ Time Frame: 2 years ]
- The nitrotyrosine and 8-isoprostane levels of exhaled breath condansate [ Time Frame: 2 years ]

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Ages Eligible for Study: | 18 Years to 75 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- hematologic malignancies or benign hematological diseases that allogeneic stem cell transplantation performed
Exclusion Criteria:
- allogeneic stem cell transplantation patients with Asthma or COPD

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02318316
Contact: Nilgün Yilmaz Demirci, MD | 009031224143 | nilgundemirci@gazi.edu.tr |
Principal Investigator: | Zeki Yıldırım, professor | Gazi University Faculty of Medicine Chest Disease Department |
Publications:
Responsible Party: | Nilgün Yılmaz Demirci, MD, Gazi University |
ClinicalTrials.gov Identifier: | NCT02318316 History of Changes |
Other Study ID Numbers: |
EBC01 |
First Posted: | December 17, 2014 Key Record Dates |
Last Update Posted: | December 17, 2014 |
Last Verified: | December 2014 |
Keywords provided by Nilgün Yılmaz Demirci, Gazi University:
Exhaled breath condensate allogeneic stem cell transplantation pulmonary complications |