Working...
ClinicalTrials.gov
ClinicalTrials.gov Menu

Protein Nutrition for Muscle Hypertrophy in Older Adults

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT02315391
Recruitment Status : Completed
First Posted : December 11, 2014
Last Update Posted : December 18, 2014
Sponsor:
Information provided by (Responsible Party):
Nestlé

Brief Summary:
The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly.

Condition or disease Intervention/treatment Phase
Healthy Elderly Muscle Anabolically Resistant Elderly Muscle Dietary Supplement: isolated whey protein Dietary Supplement: micellar whey protein Dietary Supplement: glycine Dietary Supplement: citrulline Not Applicable

Detailed Description:
The primary objective is to determine the effect of reduced activity on the stimulation of myofibrillar FSR with protein feeding in the elderly

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: Efficacy of Isolated Whey and Micellar Whey Protein (+/- Citrulline) to Stimulate Protein Synthesis in 'Healthy' and 'Anabolically Resistant' Elderly Muscle
Study Start Date : September 2012
Actual Primary Completion Date : December 2013
Actual Study Completion Date : December 2013

Resource links provided by the National Library of Medicine

Drug Information available for: Glycine

Arm Intervention/treatment
Experimental: 20g isolated whey protein + 30g carb, 8,5g fat, 15g glycine
20g isolated whey protein + 30g carb, 8,5g fat, 15g glycine
Dietary Supplement: isolated whey protein
isolated whey protein

Dietary Supplement: glycine
glycine

Experimental: 20g micellar whey protein + 30g carb, 8.5g fat, 15g glycine
20g micellar whey protein + 30g carb, 8.5g fat, 15g glycine
Dietary Supplement: micellar whey protein
micellar whey protein

Dietary Supplement: glycine
glycine

Experimental: 20g micellar whey protein + 30g carb, 8.5g fat, 5g citrulline
20g micellar whey protein + 30g carb, 8.5g fat, 5g citrulline
Dietary Supplement: micellar whey protein
micellar whey protein

Dietary Supplement: citrulline
citrulline




Primary Outcome Measures :
  1. Change in myofibrillar fractional synthetic rate (FSR) [ Time Frame: one day and 2 weeks ]

Secondary Outcome Measures :
  1. change in non-myofibrillar fractional synthetic rate (FSR) [ Time Frame: baseline and one day of feeding ]
  2. Capillary dilatation and blood flow [ Time Frame: 2 weeks ]
    Determine if inactivity reduces the feeding-induced increase in capillary dilation and nutrient delivery and whether citrulline rescues this in "resistant" muscle or augments it in the "healthy" muscle as measured by Definity infusion and contrast enhanced ultrasound (CEUS)



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   65 Years to 80 Years   (Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Must habitually complete a minimum of 5000 steps per day
  • Having obtained informed consent
  • Non-obese
  • Non-smoker

Exclusion Criteria:

  • Aged >80 years
  • Inability to comply with study procedures
  • Currently participating or having participated in another infusion trial during last 12 months
  • Any acute or chronic llness
  • History of neuromuscular problems
  • Medications known to affect protein metabolism
  • Individuals who complete fewer than 5000 steps per day
  • Individuals who have metal implants

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02315391


Sponsors and Collaborators
Nestlé
Investigators
Layout table for investigator information
Principal Investigator: Stuart Philips, PhD McMaster University

Layout table for additonal information
Responsible Party: Nestlé
ClinicalTrials.gov Identifier: NCT02315391     History of Changes
Other Study ID Numbers: 11.06.NRC
First Posted: December 11, 2014    Key Record Dates
Last Update Posted: December 18, 2014
Last Verified: November 2014

Additional relevant MeSH terms:
Layout table for MeSH terms
Glycine
Glycine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs