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Neuromuscular Control in Knee Osteoarthritis (NEKO)

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ClinicalTrials.gov Identifier: NCT02314715
Recruitment Status : Completed
First Posted : December 11, 2014
Last Update Posted : March 3, 2015
Sponsor:
Information provided by (Responsible Party):
Martijn Steultjens, Glasgow Caledonian University

Brief Summary:
Arthritis is one of the most prevailing causes of disability with knee osteoarthritis (KOA) the most common form. The lifetime risk of developing symptomatic KOA by the age of 85 years is 44.7%, where females are at a greater risk (1.8 times) than male counter parts. KOA is the leading cause of limitations in activities of daily living such as walking and climbing stairs particularly in the elderly. This is primarily due to pain and instability of the joint resulting in buckling of knees caused by muscle weakness, joint stiffness and damage. Patients with KOA have larger variations in muscle strength and are unable to maintain a target force combined with impaired ability to perceive joint movement and positioning suggests impaired neuromuscular control (NC) may influence KOA. NC refers to the nervous system's control over muscle activation contributing to task performance. This study aims to establish the role of loss of NC in biomechanical determinants and health outcomes of KOA.

Condition or disease
Osteoarthritis Knee

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Study Type : Observational
Actual Enrollment : 95 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Neuromuscular Control in Knee Osteoarthritis
Study Start Date : November 2013
Actual Primary Completion Date : February 2015
Actual Study Completion Date : February 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Osteoarthritis

Group/Cohort
Knee Osteoarthritis
Participants with diagnosed knee osteoarthritis
Controls
Participants without knee osteoarthritis



Primary Outcome Measures :
  1. Neuromuscular Control [ Time Frame: 1 day ]
    Neuromuscular control will be assessed through muscle co-activation index from electromyography (EMG) of the hamstrings, quadriceps and gastrocnemius. The electromechanical delay (delay between the onset of EMG and force), active proprioception and force accuracy and steadiness measure determined from submaximal isometric contractions will be used to determine neuromuscular control


Secondary Outcome Measures :
  1. Disease Outcome [ Time Frame: 1 day ]
    Joint damage scored using the Boston Leeds Osteoarthritis Knee Score (BLOKS) from 1.5T MRI along with pain and function assessed from knee injury and osteoarthritis score (KOOS) and patient reported outcomes measurement information system (PROMIS) will be used to determine disease outcome.


Other Outcome Measures:
  1. Determinants of knee osteoarthritis [ Time Frame: 1 day ]
    Muscle strength (peak force) will be assessed from maximal isometric contractions of the knee, along with passive motion and position sense proprioception as determinants of knee osteoarthritis.



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Ages Eligible for Study:   40 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Primary and secondary care clinics, and general community.
Criteria

Inclusion Criteria:

Knee osteoarthritis participants only:

  • Knee Osteoarthritis confirmed by a physician using the American College of Rheumatology (ACR 1986) Criteria
  • Have unilateral or bilateral knee osteoarthritis
  • Aged 40 years or over.

Healthy control participants only:

  • Have no history of unilateral/bilateral knee osteoarthritis
  • Had no current chronic/stable knee pain in the past 3 months
  • Aged 40 years or over.

Exclusion Criteria:

All participants are excluded if they:

  • Have neuromuscular skeletal injury/illness (e.g.Multiple Sclerosis, Parkinson's disease, Muscular Dystrophy, Cerebral Palsy)
  • Have had knee surgery, knee arthroplastic surgery and arthroscopic debridement or corrective surgery for knee osteoarthritis in the past 12 months
  • Have had corticosteroid injections to or around the knee in the past 3 months.
  • Have unstable heart disease
  • Previously had a stroke
  • Have insulin-dependent diabetes
  • Have osteoporosis
  • Have a history of falls and other motor deficits
  • Are unable to walk up and down stairs
  • Are unable to rise from a chair without the aid of another person
  • Have an unstable medication schedule and medication that causes dizziness
  • Have Dementia/Alzheimer's/ an inability to comprehend, follow instructions and give informed consent
  • Have an inability to lie flat for 60 minutes Have mental in their body.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02314715


Locations
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United Kingdom
Glasgow Caledonian University
Glasgow, United Kingdom, G4 0BA
Sponsors and Collaborators
Martijn Steultjens
Investigators
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Principal Investigator: Stephanie L Smith, MRes Glasgow Caledonian University

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Responsible Party: Martijn Steultjens, Professor of Musculoskeletal Health, Glasgow Caledonian University
ClinicalTrials.gov Identifier: NCT02314715     History of Changes
Other Study ID Numbers: GCU_MSK_SS_001
First Posted: December 11, 2014    Key Record Dates
Last Update Posted: March 3, 2015
Last Verified: March 2015

Keywords provided by Martijn Steultjens, Glasgow Caledonian University:
Osteoarthritis Knee

Additional relevant MeSH terms:
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Osteoarthritis
Osteoarthritis, Knee
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases