Effects of Nicotine-Free Hookah Smoking on Blood Flow to the Heart, Muscle and Skin
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|ClinicalTrials.gov Identifier: NCT02310373|
Recruitment Status : Terminated (Responsible Party/PI passed away. All subjects enrolled completed study prior to termination.)
First Posted : December 8, 2014
Last Update Posted : January 13, 2020
|Condition or disease||Intervention/treatment||Phase|
|Nicotine-free Hookah Smoking||Other: Nicotine free hookah smoking||Phase 1 Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||9 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effects of Nicotine-Free Hookah Smoking on Blood Flow to the Heart, Muscle and Skin|
|Study Start Date :||November 2014|
|Actual Primary Completion Date :||December 2018|
|Actual Study Completion Date :||December 2018|
Experimental: Nicotine free hookah (herbal/steam stones) smoking
Healthy habitual Hookah smokers will undergo microneurography, myocardial contrast echocardiogram or venous occlusion plethysmography before and after nicotine free hookah smoking.
Other: Nicotine free hookah smoking
Subjects will smoke waterpipe in a controlled research environment
- Change in sympathetic nerve activity [ Time Frame: Change from baseline in sympathetic nerve activity at 1 hr ]Multi-unit recordings of sympathetic nerve activity will be obtained with single-use sterile tungsten microelectrodes inserted selectively into muscle or skin nerve fascicles of the peritoneal nerve.
- Change in regional myocardial perfusion [ Time Frame: Change from baseline in regional myocardial perfusion at 1 hr ]Myocardial contrast echocardiography will be used to measure regional myocardial perfusion (i.e. capillary blood volume) and coronary flow reserve.
- Change in leg blood flow [ Time Frame: Change from baseline in leg blood flow at 1 hr ]Lower leg blood flow will be measured with standard venous occlusion plethysmography.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02310373
|United States, California|
|Cedars-Sinai Medical Center|
|Los Angeles, California, United States, 90048|
|Principal Investigator:||Ronald G Victor||Cedars-Sinai Medical Center|