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Cognitive Training and Practice Effects in MCI

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ClinicalTrials.gov Identifier: NCT02301546
Recruitment Status : Active, not recruiting
First Posted : November 26, 2014
Last Update Posted : August 1, 2019
Sponsor:
Collaborator:
National Institute on Aging (NIA)
Information provided by (Responsible Party):
Kevin Duff, University of Utah

Brief Summary:
The current study will test the effectiveness of a computerized cognitive (thinking) training program on improving thinking and memory in patients with mild cognitive impairment. The investigators will also examine how short term changes in thinking abilities (i.e., practice effects) can be related to improvement in thinking abilities after the cognitive training program.

Condition or disease Intervention/treatment Phase
Mild Cognitive Impairment Behavioral: computerized cognitive exercises Not Applicable

Detailed Description:
The current study will test the effectiveness of a computerized cognitive (thinking) training program on improving thinking and memory in patients with mild cognitive impairment. The investigators will also examine how short term changes in thinking abilities (i.e., practice effects) can be related to improvement in thinking abilities after the cognitive training program.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 100 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Cognitive Training and Practice Effects in MCI
Actual Study Start Date : March 2015
Estimated Primary Completion Date : January 2020
Estimated Study Completion Date : February 2020

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: experimental cognitive training
Participants will use experimental computerized cognitive training exercises, 1 hour per day, 3 - 5 days per week, for 13 weeks.
Behavioral: computerized cognitive exercises
Each group will perform computerized cognitive exercises, 1 hour per day, 3 - 5 days per week, for 13 weeks. The experimental group will use exercises shown to improve cognition, whereas the comparator group will use exercises without clear beneficial findings.

Active Comparator: control cognitive exercises
Participants will use control computerized cognitive activities, 1 hour per day, 3 - 5 days per week, for 13 weeks.
Behavioral: computerized cognitive exercises
Each group will perform computerized cognitive exercises, 1 hour per day, 3 - 5 days per week, for 13 weeks. The experimental group will use exercises shown to improve cognition, whereas the comparator group will use exercises without clear beneficial findings.




Primary Outcome Measures :
  1. cognitive score on the auditory memory composite of the Repeatable Battery of Assessment of Neuropsychological Status [ Time Frame: 13 weeks ]


Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years and older   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Mild Cognitive Impairment, amnestic subtype

    • 65 years of age or older
    • Availability of a knowledgeable informant
  • Access to internet 3 hours per week
  • Adequate vision, hearing, and motor responding to participate in training

Exclusion Criteria:

  • History of major stroke, head injury with loss of consciousness of >30 minutes, or other neurological disorder or systemic illness that are thought to be affecting cognition (e.g., seizure disorder, demyelinating disorder, etc.)
  • Current or past major psychiatric illness (e.g., schizophrenia, bipolar affective disorder)
  • History of substance abuse
  • Current use of antipsychotics or anticonvulsant medications
  • Currently residing in a nursing home or other skilled nursing facility

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02301546


Locations
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United States, Utah
University of Utah Center for Alzheimer's Care, Imaging and Research
Salt Lake City, Utah, United States, 84108
Sponsors and Collaborators
University of Utah
National Institute on Aging (NIA)

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Responsible Party: Kevin Duff, Associate Professor of Neurology, University of Utah
ClinicalTrials.gov Identifier: NCT02301546     History of Changes
Other Study ID Numbers: R01AG045163 ( U.S. NIH Grant/Contract )
First Posted: November 26, 2014    Key Record Dates
Last Update Posted: August 1, 2019
Last Verified: July 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes

Additional relevant MeSH terms:
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Cognitive Dysfunction
Cognition Disorders
Neurocognitive Disorders
Mental Disorders