Processing of Salient Emotional Stimuli as a Function of Tetrahydrocannabinol (THC) and Cannabidiol (CBD) (AB_THC_CBD)
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|ClinicalTrials.gov Identifier: NCT02291536|
Recruitment Status : Completed
First Posted : November 14, 2014
Last Update Posted : January 16, 2015
Attentional blink refers to a phenomenon where the detection of the second of two target stimuli that are presented in Short succession within a stream of stimuli is impaired. This is explained by an insufficient availability of attentional resources. Additionally, emotionally salient stimuli, like for example pictures with a positive or negative content, are detected more often compared to neutral pictures during this attentional blink period.
Cannabinoids are involved in the modulation of cognitive, attentional, and emotional processes. Interestingly, data from animals suggests that THC and CBD, both active ingredients in the Cannabis sativa plant, have opposing effects on brain cannabinoid (CB1) receptors. CB1 receptors modulate the expression of emotionally salient conditioned association in rats, if salience processes in humans are modulated in the same way remains unclear.
Employing a task to detect salient stimuli, Bhattacharyya et al. (2012) showed that THC seems to make non-salient standard stimuli more salient. They showed decreased activation of the right caudate and increased right prefrontal cortex stimuli during processing of salient stimuli. Importantly, this was associated with decreased response times to standard relative to oddball stimuli. Generally, THC and CBD differentially modulate brain areas associated with attentional salience processing. For example THC seems to increase prefrontal and striatal activation whereas CBD seems to decrease it.
The investigators assume that THC increases the number of correctly detected emotional stimuli during the attentional blink period, whereas CBD has no effect. Additionally, the investigators assume that pictures of the positive category are detected with higher accuracy than negative ones under the influence of THC.
|Condition or disease||Intervention/treatment||Phase|
|Healthy Humans||Drug: tetrahydrocannabinol Drug: cannabidiol Other: placebo||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||Double (Participant, Investigator)|
|Primary Purpose:||Basic Science|
|Official Title:||Processing of Salient Emotional Stimuli as a Function of Tetrahydrocannabinol (THC) and Cannabidiol (CBD)|
|Study Start Date :||February 2014|
|Actual Primary Completion Date :||December 2014|
|Actual Study Completion Date :||December 2014|
oral administration of 10mg of tetrahydrocannabinol, once
oral administration of cannabidiol, 600mg, once
Placebo Comparator: placebo
oral administration of placebo, once
- Correctly identified emotional pictures during the attentional blink period [ Time Frame: immediate ]Number of correctly identified emotional pictures that were presented during the attentional blink period.
- Reaction time to correctly identified emotional pictures during the attentional blink period [ Time Frame: immediate ]Reaction time (in ms) of the button press to the correctly identified emotional pictures that were presented during the attentional blink period.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02291536
|Central Institute of Mental Health|
|Mannheim, Germany, 68159|
|Principal Investigator:||Oliver Grimm, MD||Central Institute of Mental Health, Mannheim|