Creatine, Exercise and Inflammatory Markers in Knee Osteoarthritis
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|ClinicalTrials.gov Identifier: NCT02290275|
Recruitment Status : Completed
First Posted : November 14, 2014
Last Update Posted : May 16, 2016
|Condition or disease||Intervention/treatment||Phase|
|Osteoarthritis, Knee||Dietary Supplement: Creatine Other: Walking Exercise Dietary Supplement: placebo (maltodextrin)||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||30 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Triple (Participant, Investigator, Outcomes Assessor)|
|Official Title:||Creatine, Exercise and Inflammatory Markers in Knee Osteoarthritis|
|Study Start Date :||January 2015|
|Actual Primary Completion Date :||April 2016|
|Actual Study Completion Date :||April 2016|
Placebo Comparator: Placebo
The subjects in this arm will receive 20 grams of a placebo (maltodextrin) for 1 week and then 5 grams of placebo (maltodextrin) for 11 weeks in addition to their regular diets.
Dietary Supplement: placebo (maltodextrin)
Subjects will supplement their regular diet with 20 grams of maltodextrin for 1 week and then 5 grams of maltodextrin for the following 11 weeks.
The subjects in this arm will receive 20 grams of creatine for 1 week and then 5 grams of creatine for 11 weeks in addition to their regular diets.
Dietary Supplement: Creatine
Subjects will supplement their regular diet with 20 grams of creatine for 1 week and then 5 grams of creatine for the following 11 weeks.
Experimental: Walking Exercise
The subjects in this arm will receive a walking exercise program on a motorized treadmill where they will walk for 30 minutes at 3.1 mph, 3 days per week for 12 weeks.
Other: Walking Exercise
Subjects will walk on a specialized treadmill that lowers the impact of walking by taking up to 80% of their body weight away. The subjects will exercise by walking on this treadmill at 3.1 mph, 3 days per week for 30 minutes per day for 12 weeks.
- C-reactive protein [ Time Frame: 12 weeks ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02290275
|Winnipeg, Manitoba, Canada, R3M 3E4|
|Principal Investigator:||Stephen M Cornish, PhD||University of Manitoba|