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Investigating Muscle Repair in Response to Icing Therapy Post Eccentric Muscle Damage Exercise

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ClinicalTrials.gov Identifier: NCT02280668
Recruitment Status : Unknown
Verified October 2014 by Christopher Chekay, Wilfrid Laurier University.
Recruitment status was:  Recruiting
First Posted : October 31, 2014
Last Update Posted : October 31, 2014
Sponsor:
Information provided by (Responsible Party):
Christopher Chekay, Wilfrid Laurier University

Brief Summary:
The purpose of our research is to investigate the effects of applying cold therapy, or "icing," to injured muscles in terms of strength recovery and muscle soreness amelioration following unaccustomed exercise.

Condition or disease Intervention/treatment Phase
Muscle Damage Other: Icing Therapy Other: the eccentric muscle damage exercise Not Applicable

Detailed Description:
The objective is to determine whether or not injured muscles that are subject to icing after eccentrically damaging exercise recover their strength quicker and/or have less muscle soreness than those that do not receive any icing treatment after damaging exercise and if any differences in effectiveness between two icing protocols exist. Baseline measures of peak torque of the dominant arm's elbow flexor muscles will be measured by concentric and isometric contractions prior to participants undergoing eccentric muscle damaging exercise. Participants will be randomly assigned into 3 different experimental groups of approximately 15 participants each. The first group will begin "Icing Protocol 1" at time 0 (or as close to). The second group will begin "Icing Protocol 2" six hours after their initial eccentric muscle damaging exercise. The remaining group will not receive any icing treatment; they are the control group. Participants will be brought back into the lab at specific post-exercise times (0h, 24h, 48h, 96h, and 7 days) to complete peak torque measures as they did with baseline measures prior to eccentric muscle damage. Measures of delayed onset muscle soreness (DOMS) will also be taken at baseline and during scheduled follow up times for participants.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 45 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Study Start Date : October 2014
Estimated Primary Completion Date : April 2015
Estimated Study Completion Date : April 2015

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Active Comparator: Control Group
Will perform the eccentric muscle damage exercise and will not perform any icing interventions post damage. These participants will be the control group.
Other: the eccentric muscle damage exercise
Experimental: Icing Protocol 1
Will perform the eccentric muscle damage exercise and will begin the icing intervention immediately after the muscle damage. The icing protocol will be icing the elbow flexor muscles for 10 minutes with a cold pack followed by 10 minutes with no icing and another 10 minutes of elbow flexor muscle icing. The participants will perform this protocol every day at approximately the same time for the duration of the study.
Other: Icing Therapy
Participants will be randomly assigned into 3 experimental groups. Icing Protocol 1 has participants apply cold packs under the supervision of the principal investigators to their elbow flexor region for 10 minutes on, 10 minutes off, followed by an additional 10 minutes on, starting at time 0. Icing Protocol 2 follows the same procedure but it begins 6 hours after the participant has completed their eccentric muscle damaging exercise and is to be done at home without the supervision of the principal investigators. Both protocols require the participants to repeat their icing procedures every 24 hours until their involvement with the study is finished, which is 7 days in duration. The third experimental group is the control group and will not participate in an icing therapy during the duration of the study.
Other Names:
  • Cold Therapy
  • Cryotherapy

Other: the eccentric muscle damage exercise
Experimental: Icing Protocol 2
Will perform the eccentric muscle damage exercise and will begin the icing intervention 6 hours post muscle damage. The icing protocol will be icing the elbow flexor muscles for 10 minutes with a cold pack followed by 10 minutes with no icing and another 10 minutes of elbow flexor muscle icing. The participants will perform this protocol every day at approximately the same time for the duration of the study.
Other: Icing Therapy
Participants will be randomly assigned into 3 experimental groups. Icing Protocol 1 has participants apply cold packs under the supervision of the principal investigators to their elbow flexor region for 10 minutes on, 10 minutes off, followed by an additional 10 minutes on, starting at time 0. Icing Protocol 2 follows the same procedure but it begins 6 hours after the participant has completed their eccentric muscle damaging exercise and is to be done at home without the supervision of the principal investigators. Both protocols require the participants to repeat their icing procedures every 24 hours until their involvement with the study is finished, which is 7 days in duration. The third experimental group is the control group and will not participate in an icing therapy during the duration of the study.
Other Names:
  • Cold Therapy
  • Cryotherapy

Other: the eccentric muscle damage exercise



Primary Outcome Measures :
  1. Peak torque strength measures determined using the CYBEX-NORM Testing and Rehabilitation System [ Time Frame: Within 7 days post eccentric muscle damage ]
  2. Delayed onset muscle soreness determined using the VAS scale of perceived muscle soreness [ Time Frame: Within 7 days post eccentric muscle damage ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 24 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy students attending Wilfrid Laurier University with no previous history of upper body muscle damage and live in close proximity to the University so they can attend all lab sessions. Ideally they have not performed any upper body resistance training within the last 4 months.

Exclusion Criteria:

  • Previous history of muscle, joint, or ligament injuries in the surrounding area of their dominant are elbow flexor region.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02280668


Contacts
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Contact: Christopher G Chekay 647-920-6826 chek2690@mylaurier.ca
Contact: Justin D White 905-975-8017 whit3820@mylaurier.ca

Locations
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Canada, Ontario
Wilfrid Laurier University Recruiting
Waterloo, Ontario, Canada, N2L 3C5
Contact: Peter Tiidus, PhD    519-884-0710 ext 3276    ptiidus@wlu.ca   
Principal Investigator: Chris G Chekay         
Principal Investigator: Justin D White         
Sponsors and Collaborators
Wilfrid Laurier University
Investigators
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Study Director: Peter Tiidus, PhD Wilfrid Laurier University, Faculty of Health Sciences
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Responsible Party: Christopher Chekay, Undergraduate Student, Wilfrid Laurier University
ClinicalTrials.gov Identifier: NCT02280668    
Other Study ID Numbers: 4177
First Posted: October 31, 2014    Key Record Dates
Last Update Posted: October 31, 2014
Last Verified: October 2014
Keywords provided by Christopher Chekay, Wilfrid Laurier University:
muscle
muscle repair
tissue repair
eccentric exercise
force loss
icing
cold therapy
DOMS
soreness
recovery