Evaluating the Influence of Apnea on Cardiac Function Using Cardiac Magnetic Resonance Imaging.
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|ClinicalTrials.gov Identifier: NCT02280226|
Recruitment Status : Completed
First Posted : October 31, 2014
Results First Posted : February 7, 2018
Last Update Posted : February 7, 2018
University Hospital, Bonn
Information provided by (Responsible Party):
Jonas Doerner, University Hospital, Bonn
Former studies revealed a distinct pattern of changes in circulation during deliberate apnea. Blood pressure rises significantly often accompanied by bradycardia. Further studies confirmed a massive increase of total vascular resistance as it also happens in shock to maintain perfusion of heart, lung and brain. This study is to determine the exact alterations of the cardiac function during this reaction, show the redistribution of blood volume in apnea and evaluate possible longterm effects on the central nervous system caused by repeated apnea via magnetic resonance imaging.
|Condition or disease||Intervention/treatment||Phase|
|Physiological Changes in Deliberate Apnea||Device: magnetic resonance imaging (MRI)||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||17 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Evaluating the Influence of Apnea on Heart Function With Strain Analysis and Measurement of Fibrosis Derived From T1-mapping Using Cardiac Magnetic Resonance Imaging (MRI).|
|Study Start Date :||April 2014|
|Actual Primary Completion Date :||July 2016|
|Actual Study Completion Date :||July 2016|
Experimental: Deliberate Apnea Group
Subjects undergo maximum apnea.
Device: magnetic resonance imaging (MRI)
Primary Outcome Measures :
- Cardiac Function: Duration of Apnea [ Time Frame: every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements ]Alteration of cardiac function in subjects undergoing maximum apnea.
- Mean Blood Flow Measurement Under Apnea Using MRI [ Time Frame: Every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements ]Blood flow pattern in subjects undergoing maximum apnea.
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