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Evaluating the Influence of Apnea on Cardiac Function Using Cardiac Magnetic Resonance Imaging.

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ClinicalTrials.gov Identifier: NCT02280226
Recruitment Status : Completed
First Posted : October 31, 2014
Results First Posted : February 7, 2018
Last Update Posted : February 7, 2018
Sponsor:
Information provided by (Responsible Party):
Jonas Doerner, University Hospital, Bonn

Brief Summary:
Former studies revealed a distinct pattern of changes in circulation during deliberate apnea. Blood pressure rises significantly often accompanied by bradycardia. Further studies confirmed a massive increase of total vascular resistance as it also happens in shock to maintain perfusion of heart, lung and brain. This study is to determine the exact alterations of the cardiac function during this reaction, show the redistribution of blood volume in apnea and evaluate possible longterm effects on the central nervous system caused by repeated apnea via magnetic resonance imaging.

Condition or disease Intervention/treatment Phase
Physiological Changes in Deliberate Apnea Device: magnetic resonance imaging (MRI) Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 17 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Evaluating the Influence of Apnea on Heart Function With Strain Analysis and Measurement of Fibrosis Derived From T1-mapping Using Cardiac Magnetic Resonance Imaging (MRI).
Study Start Date : April 2014
Actual Primary Completion Date : July 2016
Actual Study Completion Date : July 2016

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Deliberate Apnea Group
Subjects undergo maximum apnea.
Device: magnetic resonance imaging (MRI)



Primary Outcome Measures :
  1. Cardiac Function: Duration of Apnea [ Time Frame: every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements ]
    Alteration of cardiac function in subjects undergoing maximum apnea.

  2. Mean Blood Flow Measurement Under Apnea Using MRI [ Time Frame: Every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements ]
    Blood flow pattern in subjects undergoing maximum apnea.



Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Being able to hold breath deliberately at least 4,5 minutes

Exclusion Criteria:

-

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Jonas Doerner, MD, University Hospital, Bonn
ClinicalTrials.gov Identifier: NCT02280226    
Other Study ID Numbers: UBonn-MRI-heart-14
First Posted: October 31, 2014    Key Record Dates
Results First Posted: February 7, 2018
Last Update Posted: February 7, 2018
Last Verified: February 2018
Additional relevant MeSH terms:
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Apnea
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms