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Associative Memory in Adults With an Autism Spectrum Disorder (MEM-T2A)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02279680
Recruitment Status : Unknown
Verified October 2014 by University Hospital, Caen.
Recruitment status was:  Recruiting
First Posted : October 31, 2014
Last Update Posted : October 31, 2014
Information provided by (Responsible Party):
University Hospital, Caen

Brief Summary:
The objective of this multidisciplinary project is to explore the deficit of associative memory in ASD (Autistic Spectrum Disorder) that could result from abnormal brain connectivity. The hypothesis of abnormal functioning of the fronto-hippocampal network has been evocated but has never been tested. Hence, the present project will include two complementary assessments conducted on a group of adults aged from 18 to 30 with ASD compared to a control group matched in chronological age and intellectual quotient. The first assessment is devoted to the study of associative memory and its EEG correlates and the second focused on the investigation of perceptual strategies related to associative memory using the technique of Eye-tracking. Both behavioral and imaging data would provide new insights on the relationship between perception and memory in ASD.

Condition or disease Intervention/treatment Phase
Autistic Disorder Device: Electroencephalography Behavioral: Neuropsychological assesments Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 40 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Health Services Research
Official Title: The Associative Memory in Autism Spectrum Disorders Without Intellectual Disability
Study Start Date : June 2014
Estimated Primary Completion Date : December 2015
Estimated Study Completion Date : December 2016

Arm Intervention/treatment
Adults between 18 and 30 years old right handing Patients with ASD
Device: Electroencephalography
Behavioral: Neuropsychological assesments
Healthy volunteers
Adults between 18 and 30 years old Right handing Healthy
Device: Electroencephalography
Behavioral: Neuropsychological assesments

Primary Outcome Measures :
  1. The associative memory index [ Time Frame: 2 years ]

Secondary Outcome Measures :
  1. theta and gamma oscillations during the associative memory task [ Time Frame: 2 years ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Adult between 18 and 30 years old
  • right handed
  • affiliated to the french national health care system
  • ASD only for the group of patients

Exclusion criteria :

  • mental retardation
  • schizophrenia
  • ADHD
  • brain injury with lost of consciousness
  • neurological disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02279680

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Contact: Bérengère GUILLERY-GIRARD, MCU 0231064347

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UMR1077 Inserm/EPHE/UCBN Recruiting
Caen, France, 14000
Contact: Bérengère GUILLERY-GIRARD    0231064347   
Sub-Investigator: Pierre DESAUNAY         
Sponsors and Collaborators
University Hospital, Caen
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Principal Investigator: Jean-Marc BALEYTE, PU-PH University Hospital, Caen

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Responsible Party: University Hospital, Caen Identifier: NCT02279680    
Other Study ID Numbers: 2013-AO1800-45
First Posted: October 31, 2014    Key Record Dates
Last Update Posted: October 31, 2014
Last Verified: October 2014
Additional relevant MeSH terms:
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Autism Spectrum Disorder
Autistic Disorder
Child Development Disorders, Pervasive
Neurodevelopmental Disorders
Mental Disorders