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Evaluation of Impaired Microcirculation During Septic Shock With Contrast Enhanced Ultrasound

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ClinicalTrials.gov Identifier: NCT02277977
Recruitment Status : Unknown
Verified October 2014 by Christoph Hofner, University Hospital Freiburg.
Recruitment status was:  Not yet recruiting
First Posted : October 29, 2014
Last Update Posted : October 29, 2014
Sponsor:
Information provided by (Responsible Party):
Christoph Hofner, University Hospital Freiburg

Study Description
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Brief Summary:
Microcirculatory disorders play a central role in the pathogenesis of sepsis and septic shock. Without adequate therapy that may lead to multi-organ failure and death. Therefore useful therapeutic measures aim to improve the microcirculation, to avoid tissue hypoxia and thus multiple organ failure or death. Clinically, the microcirculation can currently be indirectly evaluated using the diuresis and metabolic parameters (eg, lactate). The aim of the present study is to measure the microcirculation in septic shock by means of contrast-enhanced sonography of the calf muscles. For this purpose, the method is applied to 24 subjects during and after septic shock. It will be investigated in this study whether the microcirculation measurement with ultrasound contrast reflects the severity of the disease. As well as to evaluate whether the use of this diagnostic method could lead to better treatment of the septic shock.

Condition or disease Intervention/treatment Phase
Sepsis Other: Contrast enhanced ultrasound Not Applicable

Study Design
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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 24 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Messung Von Mikrozirkulationsstörungen im Septischen Schock Mit Kontrastmittel- verstärkter Sonographie Evaluation of Impaired Microcirculation During Septic Shock With Contrast Enhanced Ultrasound
Study Start Date : November 2014
Estimated Primary Completion Date : November 2015
Estimated Study Completion Date : December 2015

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Arms and Interventions
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Arm Intervention/treatment
Experimental: Contrast enhanced ultrasound
Contrast enhanced ultrasound during septic shock
 Other: Contrast enhanced ultrasound
Contrat enhanced ultrasound during septic shock


Outcome Measures
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Primary Outcome Measures :
  1. Contrast transit time during and after septic shock [ Time Frame: 24 months ]

Eligibility Criteria
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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • septic shock

Exclusion Criteria:

  • myocardial infarction
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02277977


Contacts
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Contact: Christoph Hofner, MD 004927076134010 christoph.schmidt-hofner@uniklinik-freiburg.de

Sponsors and Collaborators
University Hospital Freiburg
Investigators
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Study Director: Daniel Duerschmied, MD, PHD University of Freiburg
More Information
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Responsible Party: Christoph Hofner, MD, University Hospital Freiburg
ClinicalTrials.gov Identifier: NCT02277977    
Other Study ID Numbers: CUPIDDCH
First Posted: October 29, 2014    Key Record Dates
Last Update Posted: October 29, 2014
Last Verified: October 2014
Keywords provided by Christoph Hofner, University Hospital Freiburg:
sepsis
septic shock
contrast-enhanced ultrasound
microcirculation
Additional relevant MeSH terms:
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Shock, Septic
Sepsis
Infection
Systemic Inflammatory Response Syndrome
 Inflammation
Pathologic Processes
Shock