A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis (CTROP)
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|ClinicalTrials.gov Identifier: NCT02273128|
Recruitment Status : Completed
First Posted : October 23, 2014
Last Update Posted : April 21, 2015
|Condition or disease||Intervention/treatment|
|Generalized Chronic Periodontitis Osteoporosis||Genetic: CTR Gene|
Periodontitis is a polymicrobial inflammatory disease which includes various modifiable and nonmodifiable risk factors. The non modifiable risk factors include genetic polymorphisms like metabolism associated genetic polymorphisms ( Vitamin D and Calcitonin).
Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue with consequent increase in bone fragility and susceptibility to fractures.
Bone loss is a common feature shared between periodontal disease and osteoporosis.
Out of all genetic factors Calcitonin gene polymorphism contributes to the development of both osteoporosis and chronic periodontitis.
|Study Type :||Observational|
|Actual Enrollment :||50 participants|
|Observational Model:||Case Control|
|Official Title:||Calcitonin Receptor Gene Polymorphisms in Patients With Osteoporosis and Chronic Periodontitis-An Observational Study|
|Study Start Date :||June 2014|
|Actual Primary Completion Date :||October 2014|
|Actual Study Completion Date :||November 2014|
CTR Gene in Osteoporosis and Periodontitis
Patients aged between 35 - 60 yrs with Osteoporosis (BMD>-2.5) and Chronic Periodontitis (>3mm Pocket Probing Depth)
Genetic: CTR Gene
2ml blood sample collected from patients to extract DNA for Assessment of CTR Gene polymorphism
Other Name: Calcitonin Gene, Hypocalcaemic agent
- Calcitonin gene polymorphism [ Time Frame: 5 Months ]Collection of blood samples and running the samples by PCR
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02273128
|Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre|
|Hyderabad, Andhra Pradesh, India, 500060|
|Principal Investigator:||Dr.Anuradha Ankam, PG(Perio)||Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre|