Estradiol and Testosterone Levels in Seminal Plasma of Men With Non-obstructive Azoospermia
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Estradiol and Testosterone are two important hormones for the regulation of an effective spermatogenesis in human testis. The evaluation of levels of estradiol and testosterone in seminal plasma of men with non-obstructive azoospermia may be a predictive test before surgical testicular biopsy to determine the chance of a positive sperm extraction to use for ICSI.
Condition or disease
Non-obstructive Azoospermia With Testicular Biopsy for Spermatozoa Extraction
The aim of this study is to compare the levels of esttradiol and testosterone in seminal plasma of men with non-obstructive azoospermia. Indeed, for these patients, none biological test allows to predict a positive sperm extraction before the surgical testis biopsy is performed. Since the involvement of estradiol and testosterone in the regulation of spermatogenesis, the measurement of these hormones in seminal plasma may be a predictive tool for these men before testis biopsy.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 55 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Azoospermia confirmed by two semen analysis (at minimum 74 days between the both analysis)
Volume of seminal plasma >0.6ml
Testicular biopsy one month after the last semen analysis