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Proteomics to Identify Prognostic Markers After CPR and to Estimate Neurological Outcome

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02247947
Recruitment Status : Recruiting
First Posted : September 25, 2014
Last Update Posted : April 4, 2019
Sponsor:
Information provided by (Responsible Party):
Jochen Hinkelbein, Universitätsklinikum Köln

Brief Summary:
Proteomics is used to identify prognostic markers after CPR. Additionally neurological outcome should be estimated by specific protein alterations and affections of pathways.

Condition or disease
Cardiac Arrest

Detailed Description:
Proteomics is used to identify prognostic markers after CPR, i.e. altered proteins on a 2G-gel. Additionally neurological outcome should be estimated by specific protein alterations and affections of pathways.

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Study Type : Observational
Estimated Enrollment : 80 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Proteomics to Identify Prognostic Markers After CPR and to Estimate Neurological Outcome
Study Start Date : September 2014
Estimated Primary Completion Date : December 2020
Estimated Study Completion Date : December 2020

Group/Cohort
dead
Patients dead until day 20 (primary outcome measure)
survivors
patients alive after day 20 (primary outcome measure)



Primary Outcome Measures :
  1. death at day 20 [ Time Frame: day 20 ]

Biospecimen Retention:   Samples Without DNA
Serum and urine


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
patients with cardiac arrest of non-trauma origin
Criteria

Inclusion Criteria:

  • cardiac arrest

Exclusion Criteria:

  • trauma

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02247947


Contacts
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Contact: Jochen Hinkelbein, MD jochen.hinkelbein@uk-koeln.de

Locations
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Germany
University Hospital of Cologne Recruiting
Cologne, NRW, Germany, 50937
Contact: Jochen Hinkelbein, MD    +49221478 ext -97728    jochen.hinkelbein@uk-koeln.de   
Principal Investigator: Jochen Hinkelbein, MD         
Sponsors and Collaborators
Universitätsklinikum Köln
Investigators
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Study Chair: Jochen Hinkelbein, MD UK Köln

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Responsible Party: Jochen Hinkelbein, Priv.-Doz. Dr. med., Universitätsklinikum Köln
ClinicalTrials.gov Identifier: NCT02247947    
Other Study ID Numbers: 14-053
First Posted: September 25, 2014    Key Record Dates
Last Update Posted: April 4, 2019
Last Verified: April 2019
Keywords provided by Jochen Hinkelbein, Universitätsklinikum Köln:
CPR
Additional relevant MeSH terms:
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Heart Arrest
Heart Diseases
Cardiovascular Diseases