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Schizophrenia for "Life" - a Registry and Interview Study Among Elderly With Lifelong Schizophrenia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02246283
Recruitment Status : Completed
First Posted : September 22, 2014
Last Update Posted : July 17, 2018
Sponsor:
Collaborators:
The Psychiatric Research Foundation in Southern Denmark
Region of Southern Denmark
University of Southern Denmark
The Danish Mental Health Foundation
The Danish Health Foundation (Helsefonden)
The non-profit foundation Trygfonden.
Odense Patient Data Explorative Network
Jeppe Juhl and Ovita Juhls Memorial Grant
Butcher Max Wørzner and wife Inger Wørzner's Memorial Grant
Information provided by (Responsible Party):
Kjeld Andersen, University of Southern Denmark

Brief Summary:

The elderly demographic is on the rise - and this includes elderly living with schizophrenia. Yet very little is known about their lives, how they cope with their condition and how it develops over time.

Research in this patient-group is sparse; overall there seem to be a tendency for elderly patients to manifest fewer psychotic symptoms and experiencing an increase in the psychological quality of life with older age. Opinions are divided on the degree and extent to which this tendency reflects remission and/or recovery in older patients.

In order to identify factors associated with a positive outcome we:

  • Investigate the course and the outcomes of the illness over the lifespan, as well as the life course and outcomes.
  • Investigate the current status of mental and physical health, quality of life as well as functional competence of elderly (55+ yr) with schizophrenia.

Also the investigators

- Compare the trajectory and prognosis of schizophrenia (a chronic mental illness) with type 1 diabetes (a chronic somatic illness).

This study will yield vital insights into how schizophrenia develops over time, isolating factors that determine how well patients fare. The perspective is to advance knowledge of elderly with schizophrenia with a view to optimizing and increasing the effectiveness of the interventions offered to this group.


Condition or disease
Schizophrenia

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Study Type : Observational
Actual Enrollment : 10404 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Schizophrenia for "Life" - a Registry and Interview Study Among Elderly With Lifelong Schizophrenia
Study Start Date : September 2013
Actual Primary Completion Date : September 2015
Actual Study Completion Date : December 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Schizophrenia




Primary Outcome Measures :
  1. Ageing with schizophrenia [ Time Frame: up to 45 years ]
    Prognosis measured by use of healthcare system, use of medicine, co-morbidity, mortality, causes of mortality, and socio-demographic data, including highest level of education, years of employment/un-employment, use of health- and welfare services.


Secondary Outcome Measures :
  1. Quality of life [ Time Frame: 1 month ]
    Questionnaire

  2. Remission [ Time Frame: 6 months ]
    Questionnaire



Information from the National Library of Medicine

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Ages Eligible for Study:   55 Years to 95 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Registry study: A nationwide register cohort study (1970-79) identifying psychiatric admissions (aged 18-40), who were registered with a schizophrenia diagnosis. Several Danish registers are applied.

Interview study: A cross-sectional survey where 150 randomly drawn surviving members of the register cohort resident in the Region of Southern Denmark will be interviewed on the basis of internationally validated assessment tools.

Criteria

Inclusion Criteria:

Initial schizophrenia diagnosis between the ages 18-40 (both incl) in the period 1970-1979 (both incl) Interview study: Residence in Region of Southern Denmark

Exclusion Criteria:

Interview study: Mental retardation

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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02246283


Locations
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Denmark
Research Unit of Psychiatry, Psychiatric Unit Odense - University function
Odense C, Denmark, 5000
Sponsors and Collaborators
Kjeld Andersen
The Psychiatric Research Foundation in Southern Denmark
Region of Southern Denmark
University of Southern Denmark
The Danish Mental Health Foundation
The Danish Health Foundation (Helsefonden)
The non-profit foundation Trygfonden.
Odense Patient Data Explorative Network
Jeppe Juhl and Ovita Juhls Memorial Grant
Butcher Max Wørzner and wife Inger Wørzner's Memorial Grant
Investigators
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Principal Investigator: Maria Brink, MD University of Southern Denmark

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Responsible Party: Kjeld Andersen, Professor, University of Southern Denmark
ClinicalTrials.gov Identifier: NCT02246283     History of Changes
Other Study ID Numbers: Schizophrenia-Lifelong
First Posted: September 22, 2014    Key Record Dates
Last Update Posted: July 17, 2018
Last Verified: July 2018
Keywords provided by Kjeld Andersen, University of Southern Denmark:
schizophrenia
elderly
lifelong
quality of life
register
questionaire
Additional relevant MeSH terms:
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Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders