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ClinicalTrials.gov Identifier: NCT02220400
Recruitment Status : Unknown
Verified August 2014 by diansan su, RenJi Hospital. Recruitment status was: Not yet recruiting
Previous study demonstrated that neuroinflammation induced by surgery is the main cause of the postoperative cognitive dysfunction. As an agonist of NMDA receptor, ketamine is proved to be an anti-inflammation agent. In present study investigators hypothesized that low dose ketamine would prevent the cognition decline after orthopedic surgery in aged patients.
Short-term cognitive changes after surgery [ Time Frame: The day before surgery and 7 days after surgery (or before leave hospital) ]
Investigators would use mini-mental state examination(MMSE), Visual reproduction test,digit symbol，digit span,color trail test and Stroop color and word test for measuring the short-term cognitive changes of patients after surgery.
Long-term cognitive changes after surgery [ Time Frame: The day before surgery and 2 months after surgery ]
Investigators would use mini-mental state examination(MMSE), Visual reproduction test,digit symbol，digit span,color trail test and Stroop color and word test for measuring the long-term cognitive changes of patients after surgery.
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Layout table for eligibility information
Ages Eligible for Study:
60 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Elder than 60
Easily communicated with Chinese
Selected to kneel or hip replacement
Agree to take part into this clinical trail
Existing cerebral disease， or have a history of neurological and psychiatric disease including AD, stroke and psychosis
Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
Several audition or vision disorder
Preoperative systolic Blood pressure over 190mmHg or diastolic pressure >100mmHg
Existing a history of hyperthyroidism
Patient with glaucoma
Unwillingness to comply with the protocol or procedures