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Exercise Improve Sympathetic Modulation in Chronic Heart Failure Patients

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ClinicalTrials.gov Identifier: NCT02219451
Recruitment Status : Completed
First Posted : August 19, 2014
Last Update Posted : August 19, 2014
Sponsor:
Collaborator:
InCor Heart Institute
Information provided by (Responsible Party):
Raphaela Vilar Ramalho Groehs, University of Sao Paulo General Hospital

Brief Summary:
The purpose of this study is to verify the effects of exercise training on sympathetic modulation and arterial baroreflex control in patients with chronic heart failure.

Condition or disease Intervention/treatment Phase
Chronic Heart Failure Other: exercise training Phase 4

Detailed Description:
Retrospective study. Patients were recruited by database from Rehabilitation Unit of Cardiovascular Rehabilitation and Exercise Physiology of the Heart Institute (InCor). The aim of this study is to assess the effects of exercise training on sympathetic modulation and arterial baroreflex control in patients with chronic heart failure. The investigators studied twenty-six chronic heart failure outpatients, age 30 to 70 years, functional class II to III of New York Heart Association, left ventricular ejection fraction (LVEF) ≤40% and peak oxygen uptake (VO2) ≤20. The exclusion criteria were recent myocardial infarction or unstable angina (<3 months), heart failure duration (<3 months), permanent pacemaker dependence, atrial fibrillation, skeletal muscle abnormality (e.g., arthritis) and participation in a regular exercise program. They were assigned to 2 groups: Untrained (n=13) and trained (n=13).

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 26 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: Single (Participant)
Official Title: Exercise Training Improves Oscillatory Pattern and Arterial Baroreflex Control of Sympathetic Nerve Activity in Patients With Chronic Heart Failure
Study Start Date : August 2013
Actual Primary Completion Date : April 2014
Actual Study Completion Date : July 2014

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: exercise training
We studied twenty-six chronic heart failure outpatients and they were assigned to 2 groups: Untrained (n=13) and trained (n=13).
Other: exercise training
exercise training




Primary Outcome Measures :
  1. Autonomic control [ Time Frame: 4 months ]
    To asses the effects of exercise training on sympathetic modulation by analyze of autonomic control in chronic heart failure patients after 4 months protocol.Time series of muscle sympathetic nerve activity and systolic arterial pressure were analyzed by autoregressive spectral analysis


Secondary Outcome Measures :
  1. Arterial baroreflex control [ Time Frame: 4 months ]
    To asses the effects of exercise training on arterial baroreflex by analyze of arterial baroreflex control in chronic heart failure patients after 4 months. The arterial baroreflex control was analyzed by bivariate autoregressive.



Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients with chronic heart failure
  • Age 30 to 70 years
  • Functional class II to III of New York Heart Association
  • Left ventricular ejection fraction (LVEF) ≤40%
  • Peak oxygen uptake (VO2) ≤20

Exclusion Criteria:

  • Recent myocardial infarction or unstable angina (<3 months)
  • heart failure duration (<3 months)
  • Permanent pacemaker dependence
  • Atrial fibrillation
  • Skeletal muscle abnormality (e.g., arthritis)
  • Participation in a regular exercise program

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02219451


Locations
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Brazil
Instituto do Coração - HC/FMUSP
Sao Paulo, Brazil, 05403-900
Sponsors and Collaborators
University of Sao Paulo General Hospital
InCor Heart Institute
Investigators
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Principal Investigator: Heart Institute HC/FMUSP, HC/FMUSP Heart Institute, University of Sao Paulo
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Raphaela Vilar Ramalho Groehs, PhD student, University of Sao Paulo General Hospital
ClinicalTrials.gov Identifier: NCT02219451    
Other Study ID Numbers: sympathetic modulation
First Posted: August 19, 2014    Key Record Dates
Last Update Posted: August 19, 2014
Last Verified: August 2014
Keywords provided by Raphaela Vilar Ramalho Groehs, University of Sao Paulo General Hospital:
Chronic heart failure
exercise training
Sympathetic modulation
arterial baroreflex control
Additional relevant MeSH terms:
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Heart Failure
Heart Diseases
Cardiovascular Diseases