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Early Waning of Maternal Measles and Meningitis C Antibodies (EWMM)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02219061
Recruitment Status : Unknown
Verified August 2014 by Guangzhou Center for Disease Control and Prevention.
Recruitment status was:  Recruiting
First Posted : August 18, 2014
Last Update Posted : September 18, 2014
Sponsor:
Information provided by (Responsible Party):
Guangzhou Center for Disease Control and Prevention

Brief Summary:

Maternal antibodies (measles and meningitis C) may wane in the first six months after birth.

  • Geometric mean titers(GMTs) of measles and meningitis C.
  • Follow-up on 0 month, 3rd month,5th month and 7th month after birth.

Condition or disease
Measles

Detailed Description:

Measles and meningitis C are hot topics in China in recent years. Although China had set the goal of measles elimination, many measles cases were found to be those aged < 8 months and meningitis C is becoming public health issue since meningitis group A has been controlled at a very low level and little is known on C group. So the investigators designed the observation study on the two antibodies.

Maternal antibodies are supposed to wane after birth. Serums of the placenta(0 month), children of 3 months, 5 months and 7 months old will be collected and the geometric mean titers (GMTs) of measles and meningitis C will be confirmed by using the ELISA test.

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Study Type : Observational
Estimated Enrollment : 100 participants
Time Perspective: Prospective
Official Title: Observation Study on Early Waning of Maternal Measles and Meningitis C Antibodies
Study Start Date : May 2014
Estimated Primary Completion Date : October 2014
Estimated Study Completion Date : December 2014


Group/Cohort
GMT



Primary Outcome Measures :
  1. Geometric Mean Titer [ Time Frame: Up to six months ]

Biospecimen Retention:   Samples Without DNA
Children's Serum will be collected for measles and meningitis C antibodies test by ELISA method.


Information from the National Library of Medicine

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Ages Eligible for Study:   up to 7 Months   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Infants.
Criteria

Inclusion Criteria:

  • Healthy infants.

Exclusion Criteria:

  • Infants with poor score.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02219061


Contacts
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Contact: Chuanxi Fu, PhD +86 20 36055887 fuchuanxi@gmail.com

Locations
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China, Guangdong
Guangzhou Center for Disease Control and Prevention Recruiting
Guangzhou, Guangdong, China, 510440
Contact: Chuanxi    +86 20 36055887      
Contact: Ming       48280698@qq.com   
Sub-Investigator: Long Lu, MPH         
Sponsors and Collaborators
Guangzhou Center for Disease Control and Prevention
Investigators
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Principal Investigator: Ming Wang Guangzhou CDC
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Responsible Party: Guangzhou Center for Disease Control and Prevention
ClinicalTrials.gov Identifier: NCT02219061    
Other Study ID Numbers: GZCDC001
First Posted: August 18, 2014    Key Record Dates
Last Update Posted: September 18, 2014
Last Verified: August 2014
Keywords provided by Guangzhou Center for Disease Control and Prevention:
Measles
Meningitis C
waning
Geometric Mean Titer
China
Additional relevant MeSH terms:
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Meningococcal Infections
Measles
Meningitis
Central Nervous System Diseases
Nervous System Diseases
Neisseriaceae Infections
Gram-Negative Bacterial Infections
Bacterial Infections
Morbillivirus Infections
Paramyxoviridae Infections
Mononegavirales Infections
RNA Virus Infections
Virus Diseases