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Comparison Between Propofol-remifentanil Total Intravenous Anesthesia and Desflurane-remifentanil Balanced Anesthesia With Regard to Post-anesthetic Functional Recovery Measured With QoR-40 in Vitrectomy

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ClinicalTrials.gov Identifier: NCT02212340
Recruitment Status : Completed
First Posted : August 8, 2014
Last Update Posted : September 27, 2016
Sponsor:
Information provided by (Responsible Party):
Yonsei University

Brief Summary:
Total intravenous anesthesia (TIVA) and inhalation anesthesia are both widely and safely used, and there are many clinical trials comparing these on various aspects of anesthesia. However, there have not been studies comparing the quality of recovery from the different methods of general anesthesia in vitrectomy. In this study, the investigators compare the functional recovery after general anesthesia in TIVA and inhalation anesthesia with QoR-40 questionnaire in vitrectomy.

Condition or disease Intervention/treatment Phase
Vitrectomy Operation Under General Anesthesia Drug: fresofol and remifentanil Drug: desflurane and remifentanil Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 84 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Prevention
Study Start Date : July 2014
Actual Primary Completion Date : January 2016
Actual Study Completion Date : March 2016

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: TIVA group
Anesthesia is maintained with fresofol and remifentanil
Drug: fresofol and remifentanil
Anesthesia is maintained with fresofol and remifentanil in TIVA group or with desflurane and remifentanil in Des group according to randomly allocated group.

Active Comparator: Des group
Anesthesia is maintained with desflurane and remifentanil
Drug: desflurane and remifentanil
Anesthesia is maintained with fresofol and remifentanil in TIVA group or with desflurane and remifentanil in Des group according to randomly allocated group.




Primary Outcome Measures :
  1. QoR-40 score [ Time Frame: at 6 hours later after surgery ]


Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Patients (20-80 years old) scheduled for vitrectomy surgery undergoing general anesthesia.
  2. ASA 1-3

Exclusion Criteria:

  1. Patients with allergy to anesthetic agents
  2. Anticipated difficult airway
  3. BMI > 30 kg/m2
  4. Chronic obstructive pulmonary disease
  5. Heart failure 6. Unstable angina

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02212340


Locations
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Korea, Republic of
Gangnam Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of, 120-752
Sponsors and Collaborators
Yonsei University

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Responsible Party: Yonsei University
ClinicalTrials.gov Identifier: NCT02212340    
Other Study ID Numbers: 3-2014-0104
First Posted: August 8, 2014    Key Record Dates
Last Update Posted: September 27, 2016
Last Verified: September 2016
Keywords provided by Yonsei University:
propofol
desflurane
quality of recovery
vitrectomy
Additional relevant MeSH terms:
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Remifentanil
Anesthetics
Propofol
Desflurane
Central Nervous System Depressants
Physiological Effects of Drugs
Hypnotics and Sedatives
Anesthetics, Intravenous
Anesthetics, General
Analgesics, Opioid
Narcotics
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Anesthetics, Inhalation