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5 Years Mortality-rate in Patients Treated for Severe Pneumonia in an ICU - a Retrospective Study (pneumonia)

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ClinicalTrials.gov Identifier: NCT02212093
Recruitment Status : Completed
First Posted : August 8, 2014
Last Update Posted : July 23, 2015
Sponsor:
Collaborator:
Oslo University Hospital
Information provided by (Responsible Party):
Vegard Dahl, University Hospital, Akershus

Brief Summary:
Severe pneumonia has a high in-hospital mortality. There are few studies which investigate the long-term mortality in patients that are discharged alive from the hospital. In this study we want to investigate the 5 years mortality after treatment of severe pneumonia in an ICU. We will also investigate the cause of death after discharge from the hospital.

Condition or disease
Pneumonia

Detailed Description:

Patients with severe pneumonia who need treatment in an ICU have a high in-hospital mortality (16-46%). There are few studies which investigate the long-term mortality (> 1year) in patients after discharge from the hospital. There seems to be a higher mortality in this group compared to the general population. The cause(s) of this higher long-term mortality is unclear and few studies have investigated this problem.

We are going to investigate the 5 years mortality rate in this population of patients. We are also going to investigate the cause of death in the patients who are discharged from the hospital alive.

Inclusion criteria: Patients > 18 years. Primary diagnose: pneumonia, and the need of mechanical ventilation for at least 24 hours in an ICU. The patients who arrive at the ICU in Akershus University Hospital in the period from 01.01.1997 to 31.12.2006.

The datas are collected from the patients' journals and the local ICU register. Collecting data: Age, sex, comorbidity, SAPSII, mechanical ventilation time, stay in the ICU, stay in the hospital, ICU mortality, hospital mortality, 5 years mortality, type of pneumonia (bacteriology).

Time of death after discharge is collected from Norwegian National Registry. Cause of death after discharge is collected from Norwegian Institute of Public Health.


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Study Type : Observational
Actual Enrollment : 236 participants
Time Perspective: Retrospective
Official Title: Cause-specific 5 Years Mortality-rate in Patients Treated for Severe Pneumonia in an ICU - a Retrospective Study
Study Start Date : June 2014
Actual Primary Completion Date : February 2015
Actual Study Completion Date : February 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Pneumonia

Group/Cohort
pneumonia and mechanical ventilation
The data are collected retrospectively from this one group.



Primary Outcome Measures :
  1. 5 years mortality [ Time Frame: 5 years ]

Secondary Outcome Measures :
  1. cause of death after discharge from the hospital [ Time Frame: 5 years ]

Biospecimen Retention:   Samples Without DNA
Bacteriology tests


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The same as the inclusion criteria
Criteria

Inclusion Criteria:

  • Patients > 18 years. Primary diagnose: pneumonia, and the need of mechanical ventilation for at least 24 hours in an ICU. The patients who arrived the ICU in Akershus University Hospital in the period from 01.01.1997 to 31.12.2006.

Exclusion Criteria:

  • Patients < 18 years. Patients with need for mechanical ventilation < 24 hours

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02212093


Locations
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Norway
Akershus University Hospital
Nordbyhagen, Akershus, Norway, 1478
Sponsors and Collaborators
University Hospital, Akershus
Oslo University Hospital
Investigators
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Principal Investigator: Vegard Dahl, Professor University Hospital, Akershus

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Responsible Party: Vegard Dahl, Professor, University Hospital, Akershus
ClinicalTrials.gov Identifier: NCT02212093     History of Changes
Other Study ID Numbers: 2013/2338
First Posted: August 8, 2014    Key Record Dates
Last Update Posted: July 23, 2015
Last Verified: July 2015
Keywords provided by Vegard Dahl, University Hospital, Akershus:
Pneumonia, mechanical ventilation, ICU, mortality
Additional relevant MeSH terms:
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Pneumonia
Lung Diseases
Respiratory Tract Diseases
Respiratory Tract Infections