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Trial record 2 of 45 for:    graves disease | Recruiting, Not yet recruiting, Available Studies

Next-generation Sequencing (NGS) of Peripheral Blood Immune Repertoire in Graves' Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT02210741
Recruitment Status : Not yet recruiting
First Posted : August 7, 2014
Last Update Posted : August 7, 2014
Information provided by (Responsible Party):
National Taiwan University Hospital

Brief Summary:
Graves' disease (MIM 27500) is the leading cause of hyperthyroidism worldwide. The prevalence of Graves' disease is quite high (2.7% in women), and there is solid evidence of genetic predisposition. Despite its clinical and scientific significance, Graves' disease is still mysterious in terms of its susceptibility genes or pathophysiological mechanisms. The immune repertoire, being the sum of T and B lymphocytes in a body at any given time, is both a snapshot and a historical record of a person's immune function. Thanks to the power of next-generation sequencing (NGS), massively parallel sequencing of the B cell and T cell receptors suddenly becomes plausible, and opens a door for many creative approaches to study immune related diseases. The ultimate goal of this project is to use both the NGS deep sequencing and immune repertoire experiment to perform Graves' disease sub-group genetic fine mapping, and to identify Graves' disease-specific T cell and B cell receptors. Furthermore, using the immune repertoire approach, investigators want to study the critical epitopes of thyroid auto-antigens, and to delineate the pathophysiological steps in various disease stages and in various sub-groups. Investigators expect to solve the immune repertoire of Graves' disease of different sub-group presentations and at various disease activity stages.

Condition or disease
Graves Disease

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Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Next-generation Sequencing (NGS) of Peripheral Blood Immune Repertoire in Graves' Disease
Study Start Date : August 2014
Estimated Primary Completion Date : February 2024
Estimated Study Completion Date : February 2024

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. B lymphocyte and T lymphocyte receptor profiles of Graves' disease patients [ Time Frame: Three years ]
    "B lymphocyte and T lymphocyte receptor profiles" mean the sequence of the receptors and also the quantity of the lymphocytes with those specific receptor sequences.

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patient from our hospital, National Taiwan University Hospital
Patients with Graves disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02210741

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Contact: Pei-Lung Chen 886-2-23123456 ext 71942

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National Taiwan University Hospital Not yet recruiting
Taipei City, Taiwan, 100
Sponsors and Collaborators
National Taiwan University Hospital
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Principal Investigator: Tien-Chun Chang Professor of Department of Internal Medicine, National Taiwan University

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Responsible Party: National Taiwan University Hospital Identifier: NCT02210741     History of Changes
Other Study ID Numbers: 201312091RINB
First Posted: August 7, 2014    Key Record Dates
Last Update Posted: August 7, 2014
Last Verified: August 2014
Keywords provided by National Taiwan University Hospital:
immune repertoire
Graves' disease
Additional relevant MeSH terms:
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Graves Disease
Orbital Diseases
Eye Diseases
Thyroid Diseases
Endocrine System Diseases
Autoimmune Diseases
Immune System Diseases