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Postural Changes in Lung Volumes in Obesity

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ClinicalTrials.gov Identifier: NCT02207192
Recruitment Status : Completed
First Posted : August 4, 2014
Last Update Posted : August 6, 2014
Sponsor:
Information provided by (Responsible Party):
Association pour la Formation du Personnel à la Medecine d'Urgence

Brief Summary:
Postural changes are known to affect normal lung volumes. A reduction in sitting to supine functional residual capacity (FRC) is well-described in non-obese subjects adopting a supine position. However, postural changes in lung volumes in the obese require further exploration. We aimed to longitudinally address the effects of weight loss on postural changes in lung volumes and pulmonary function, in obesity. We tested the hypothesis that supine reduction in FRC would be absent in morbid obesity and recovered upon weight loss.

Condition or disease Intervention/treatment
Obesity Other: Postural change in lung volumes: sitting to Supine

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Study Type : Observational
Actual Enrollment : 12 participants
Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: Effect of Weight Loss on Postural Changes in Pulmonary Function : a Longitudinal Study in Morbidly Obese to Obese Subjects Following Gastroplasty
Study Start Date : August 2005
Actual Primary Completion Date : October 2008
Actual Study Completion Date : October 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Weight Control

Group/Cohort Intervention/treatment
Morbidly obese
Consecutive morbidly obese adults (BMI over or equal to 40 kg/m2) scheduled for bariatric surgery were prospectively recruited.Subjects with respiratory and cardiac history (asthma, Chronic obstructive pulmonary disease, heart failure) were excluded.
Other: Postural change in lung volumes: sitting to Supine

Pulmonary function and arterial blood gases were assessed both prior to and after weight loss as part of pre-operative and 12-month follow-up evaluations.

Pulmonary function tests were performed both in the sitting and then in the supine position.





Primary Outcome Measures :
  1. functional residual capacity [ Time Frame: baseline and one year after bariatric surgery ]

Secondary Outcome Measures :
  1. lung volumes and flows [ Time Frame: at baseline and after bariatric surgery ]


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Ages Eligible for Study:   up to 60 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Twelve morbidly obese adults (BMI over or equal to 40 kg/m2) scheduled for bariatric surgery at the Montpellier university hospital were recruited. They were 3 men and 9 women.
Criteria

Inclusion Criteria:

  • subjects scheduled for bariatric surgery (BMI over or equal to 40 kg/m2)

Exclusion Criteria:

  • Subjects with respiratory and cardiac history (asthma, COPD, heart failure) were excluded.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02207192


Locations
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France
Montpellier University hospital
Montpellier, France, 34295
Sponsors and Collaborators
Association pour la Formation du Personnel à la Medecine d'Urgence
Investigators
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Principal Investigator: Mustapha Sebbane, MD, PhD Montpellier University Hospital

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Association pour la Formation du Personnel à la Medecine d'Urgence
ClinicalTrials.gov Identifier: NCT02207192     History of Changes
Other Study ID Numbers: FRC obesity
First Posted: August 4, 2014    Key Record Dates
Last Update Posted: August 6, 2014
Last Verified: August 2014
Keywords provided by Association pour la Formation du Personnel à la Medecine d'Urgence:
obesity, lung volumes, postural changes
Additional relevant MeSH terms:
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Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms