Effect of Normal Aging on Language Processing (SEMVIE)
|ClinicalTrials.gov Identifier: NCT02189460|
Recruitment Status : Terminated (Not enough subjects)
First Posted : July 14, 2014
Last Update Posted : October 12, 2018
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||33 participants|
|Official Title:||Cognitive Mechanisms and Cerebral Substrate of Naming Impairment During Aging. Behavior and Neuroimaging Approaches.|
|Study Start Date :||July 2014|
|Actual Primary Completion Date :||July 2018|
|Actual Study Completion Date :||July 2018|
20 young adults aged between 30 and 50 years old. 20 middle aged adults aged between 50 and 70 years old. 20 older adults of 70 years old and more.
- Blood Oxygen Level Dependent functional MRI [ Time Frame: There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year. ]
We use 3 functional tasks using block paradigm: Object naming, Verbal generation and semantic judgment, to elicit BOLD response using fMRI in order to compare functional activation patterns between subjects.
We also use hypercapnic challenge to elicit BOLD response in order to obtain Cerebral Vascular Reactivity properties of subjects.
- Anatomical MRI [ Time Frame: There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year. ]
We use Voxel Based Morphometry to compare cortical volume (grey matter) between subjects.
We also use tractography Diffusion Tensor Imaging to compare white matter properties between subjects.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02189460
|Grenoble, France, 38000|
|Principal Investigator:||Alexandre Krainik, Professor||Neuroradiology department, Grenoble Hospital, INSERM, Grenoble University.|
|Study Director:||Monica Baciu, Professor||Laboratory of Psychology and NeuroCognition, CNRS, Grenoble University.|