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Effect of Normal Aging on Language Processing (SEMVIE)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02189460
Recruitment Status : Terminated (Not enough subjects)
First Posted : July 14, 2014
Last Update Posted : October 12, 2018
Sponsor:
Information provided by (Responsible Party):
University Hospital, Grenoble

Brief Summary:
The purpose of this study is to understand the effect of age on language abilities. The investigators aim at investigating the cerebral modifications that take place in normal aging, at the functional an anatomical level.

Condition or disease
Cognition

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Study Type : Observational
Actual Enrollment : 33 participants
Observational Model: Other
Time Perspective: Prospective
Official Title: Cognitive Mechanisms and Cerebral Substrate of Naming Impairment During Aging. Behavior and Neuroimaging Approaches.
Study Start Date : July 2014
Actual Primary Completion Date : July 2018
Actual Study Completion Date : July 2018

Group/Cohort
Healthy adults
20 young adults aged between 30 and 50 years old. 20 middle aged adults aged between 50 and 70 years old. 20 older adults of 70 years old and more.



Primary Outcome Measures :
  1. Blood Oxygen Level Dependent functional MRI [ Time Frame: There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year. ]

    We use 3 functional tasks using block paradigm: Object naming, Verbal generation and semantic judgment, to elicit BOLD response using fMRI in order to compare functional activation patterns between subjects.

    We also use hypercapnic challenge to elicit BOLD response in order to obtain Cerebral Vascular Reactivity properties of subjects.


  2. Anatomical MRI [ Time Frame: There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year. ]

    We use Voxel Based Morphometry to compare cortical volume (grey matter) between subjects.

    We also use tractography Diffusion Tensor Imaging to compare white matter properties between subjects.




Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

60 healthy adults will participate to the study. There will be 3 age groups: 30-50, 50-70, > 70 years. Ech group will contain 20 volunteers.

The volunteers are recruited by means of ads on Laboratory websites and Universities.

Criteria

Inclusion Criteria:

  • Age of 30 years and above
  • Right handed
  • French native speakers
  • Affiliation to French social security (Sécurité Sociale)
  • Medical interview
  • Consent form signed

Exclusion Criteria:

  • Cerebral or respiratory pathologies
  • Any MRI contrindication

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02189460


Locations
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France
IRMaGe facility
Grenoble, France, 38000
Sponsors and Collaborators
University Hospital, Grenoble
Investigators
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Principal Investigator: Alexandre Krainik, Professor Neuroradiology department, Grenoble Hospital, INSERM, Grenoble University.
Study Director: Monica Baciu, Professor Laboratory of Psychology and NeuroCognition, CNRS, Grenoble University.
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Responsible Party: University Hospital, Grenoble
ClinicalTrials.gov Identifier: NCT02189460    
Other Study ID Numbers: 2014-AZ00569-38
First Posted: July 14, 2014    Key Record Dates
Last Update Posted: October 12, 2018
Last Verified: October 2018
Keywords provided by University Hospital, Grenoble:
Cognition