Effect of Normal Aging on Language Processing (SEMVIE)
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT02189460 |
Recruitment Status :
Terminated
(Not enough subjects)
First Posted : July 14, 2014
Last Update Posted : October 12, 2018
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease |
---|
Cognition |
Study Type : | Observational |
Actual Enrollment : | 33 participants |
Observational Model: | Other |
Time Perspective: | Prospective |
Official Title: | Cognitive Mechanisms and Cerebral Substrate of Naming Impairment During Aging. Behavior and Neuroimaging Approaches. |
Study Start Date : | July 2014 |
Actual Primary Completion Date : | July 2018 |
Actual Study Completion Date : | July 2018 |
Group/Cohort |
---|
Healthy adults
20 young adults aged between 30 and 50 years old. 20 middle aged adults aged between 50 and 70 years old. 20 older adults of 70 years old and more.
|
- Blood Oxygen Level Dependent functional MRI [ Time Frame: There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year. ]
We use 3 functional tasks using block paradigm: Object naming, Verbal generation and semantic judgment, to elicit BOLD response using fMRI in order to compare functional activation patterns between subjects.
We also use hypercapnic challenge to elicit BOLD response in order to obtain Cerebral Vascular Reactivity properties of subjects.
- Anatomical MRI [ Time Frame: There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year. ]
We use Voxel Based Morphometry to compare cortical volume (grey matter) between subjects.
We also use tractography Diffusion Tensor Imaging to compare white matter properties between subjects.

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 30 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
60 healthy adults will participate to the study. There will be 3 age groups: 30-50, 50-70, > 70 years. Ech group will contain 20 volunteers.
The volunteers are recruited by means of ads on Laboratory websites and Universities.
Inclusion Criteria:
- Age of 30 years and above
- Right handed
- French native speakers
- Affiliation to French social security (Sécurité Sociale)
- Medical interview
- Consent form signed
Exclusion Criteria:
- Cerebral or respiratory pathologies
- Any MRI contrindication

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02189460
France | |
IRMaGe facility | |
Grenoble, France, 38000 |
Principal Investigator: | Alexandre Krainik, Professor | Neuroradiology department, Grenoble Hospital, INSERM, Grenoble University. | |
Study Director: | Monica Baciu, Professor | Laboratory of Psychology and NeuroCognition, CNRS, Grenoble University. |
Responsible Party: | University Hospital, Grenoble |
ClinicalTrials.gov Identifier: | NCT02189460 |
Other Study ID Numbers: |
2014-AZ00569-38 |
First Posted: | July 14, 2014 Key Record Dates |
Last Update Posted: | October 12, 2018 |
Last Verified: | October 2018 |
Cognition |