Diagnostic Test for Endometrial Receptivity 24 Hours Before Embryo Transfer
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ClinicalTrials.gov Identifier: NCT02189369 |
Recruitment Status : Unknown
Verified March 2017 by Carlos Simon, Igenomix.
Recruitment status was: Recruiting
First Posted : July 14, 2014
Last Update Posted : March 7, 2017
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Infertility | Other: Day 3 embryo transfer Other: Day 5 embryo transfer | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 120 participants |
Allocation: | Non-Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Basic Science |
Official Title: | Clinical Validation of a Diagnostic Test Which Measures the Endometrial Prostaglandins Liquid 24 Hours Before Embryo Transfer and That is Capable of Predicting a State of Endometrial Receptivity |
Study Start Date : | February 2015 |
Estimated Primary Completion Date : | September 2017 |
Estimated Study Completion Date : | December 2017 |
Arm | Intervention/treatment |
---|---|
Experimental: Day 3 embryo-Own-above cutoff
Day 3 embryo transfer for IVF with own oocytes, and prostaglandine levels with higher receptivty rates
|
Other: Day 3 embryo transfer
Extraction of endometrial fluid, analysis of prostaglandine and Day 3 embryo transfer |
Experimental: Day 5 embryo-Own-above cutoff
Day 5 embryo transfer for IVF with own oocytes, and prostaglandine levels with higher receptivty rates
|
Other: Day 5 embryo transfer
Extraction of endometrial fluid, analysis of prostaglandine and Day 5 embryo transfer |
Experimental: Day 3 embryo-Donor-above cutoff
Day 3 embryo transfer for IVF with donor oocytes, and prostaglandine levels with higher receptivty rates
|
Other: Day 3 embryo transfer
Extraction of endometrial fluid, analysis of prostaglandine and Day 3 embryo transfer |
Experimental: Day 5 embryo-Donor- above cutoff
Day 5 embryo transfer for IVF with donor oocytes, and prostaglandine levels with higher receptivty rates
|
Other: Day 5 embryo transfer
Extraction of endometrial fluid, analysis of prostaglandine and Day 5 embryo transfer |
Experimental: Day 3 embryo-Donor-lower cutoff
Day 3 embryo transfer for IVF with donor oocytes, and prostaglandine levels with lower receptivty rates
|
Other: Day 3 embryo transfer
Extraction of endometrial fluid, analysis of prostaglandine and Day 3 embryo transfer |
Experimental: Day 5 embryo-Donor-lower cutoff
Day 5 embryo transfer for IVF with donor oocytes, and prostaglandine levels with lower receptivty rates
|
Other: Day 5 embryo transfer
Extraction of endometrial fluid, analysis of prostaglandine and Day 5 embryo transfer |
Experimental: Day 3 embryo-own-lower cutoff
Day 3 embryo transfer for IVF with own oocytes, and prostaglandine levels with lower receptivty rates
|
Other: Day 3 embryo transfer
Extraction of endometrial fluid, analysis of prostaglandine and Day 3 embryo transfer |
Experimental: Day 5 embryo-own-lower cutoff
Day 5 embryo transfer for IVF with own oocytes, and prostaglandine levels with lower receptivty rates
|
Other: Day 5 embryo transfer
Extraction of endometrial fluid, analysis of prostaglandine and Day 5 embryo transfer |
- endometrial receptivity [ Time Frame: 24 hours before embryo transfer ]The endometrial samples will be extracted 24 hours before the embryo transfer in order to analyze the quantity of prostaglandins.
- Implantation rate [ Time Frame: 15 days ]We will reffer a correlation between the prostaglandin results and the implantation rate.
- Pregnancy rate [ Time Frame: 15 days ]We will reffer a correlation between the prostaglandin results and the implantation rate.

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Ages Eligible for Study: | 18 Years to 50 Years (Adult) |
Sexes Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Any IVF patient being treated for single or double embryo transfer
- BMI: 20 - 30
- Normal ovarian response (7 - 8 ovocitos) in IVF treatment with AFC ≥ 8, (AFC = Antral Follicle Count)
- Elective embryo transfer
- Normal uterine cavity
- Age: ≤ 38 years old for patients with own oocytes; ≤ 50 years old for patients with donated oocytes.
Exclusion Criteria:
- Patients with recurrent miscarriages ( ≥ 2 biochemical miscarriages; ≥ 2 clinical miscarriage)
- Patients with severe male factor ( ≥ 2*106 espermatozoides/ml).

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02189369
Contact: Carlos Gómez, MA | +34670506469 | carlos.gomez@igenomix.com |
Spain | |
Fundación IVI | Recruiting |
Valencia, Spain, 46015 | |
Contact: Carlos Gómez, Ma +34670506469 carlos.gomez@igenomix.com | |
Principal Investigator: Carlos Simón, MD, PhD | |
Sub-Investigator: Felip Vilella, PhD | |
IVI Valencia | Recruiting |
Valencia, Spain, 46015 | |
Contact: Carlos Gómez, MA carlos.gomez@igenomix.com | |
Principal Investigator: Carlos Simón, MD, PhD | |
Sub-Investigator: Marcos Meseguer, PhD | |
Sub-Investigator: Sergio Cabanillas, MD |
Principal Investigator: | Carlos Simon, MD PhD | Fundación IVI |
Responsible Party: | Carlos Simon, Dr. Carlos Simón, Igenomix |
ClinicalTrials.gov Identifier: | NCT02189369 |
Other Study ID Numbers: |
1311-FIVI-135-CS |
First Posted: | July 14, 2014 Key Record Dates |
Last Update Posted: | March 7, 2017 |
Last Verified: | March 2017 |
Infertility |