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Effects of Yoga on Bone Metabolism in Premenopausal Women

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ClinicalTrials.gov Identifier: NCT02163668
Recruitment Status : Completed
First Posted : June 16, 2014
Last Update Posted : June 16, 2014
Sponsor:
Information provided by (Responsible Party):
Debra Bemben, University of Oklahoma

Brief Summary:
This study examined the effects of 8 months of Yoga training on bone density and bone turnover markers in premenopausal women, ages 35-50 years. The style of Yoga used was power Yoga that involved postures with a jumping component. The investigators hypothesized that the Yoga intervention would result in beneficial improvements in bone turnover markers, by increasing the bone formation marker and decreasing the bone resorption marker.

Condition or disease Intervention/treatment Phase
Bone Health Osteoporosis Other: Yoga Group Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 47 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Effects of an 8-month Yoga Intervention on Bone Metabolism in Healthy Middle-aged Premenopausal Women: A Randomized Controlled Study
Study Start Date : September 2009
Actual Primary Completion Date : June 2010
Actual Study Completion Date : April 2012

Arm Intervention/treatment
Experimental: Yoga group
8 months of progressive Yoga training
Other: Yoga Group
8 months of Yoga training

No Intervention: Control group
No training, just pre and post testing



Primary Outcome Measures :
  1. Change in bone mineral density from baseline to 8 months [ Time Frame: pre and post 8 months training ]
  2. change in bone turnover markers [ Time Frame: pre and post 8 month intervention ]
  3. change in tibia bone characteristics [ Time Frame: pre and post 8 month intervention ]
    changes in volumetric bone mineral density and bone strength of the non-dominant tibia assessed by peripheral Quantitative Computed Tomography (pQCT)

  4. Changes in muscular strength [ Time Frame: pre and post 9 month intervention ]
    Isotonic 1 repetition maximum (1RM) for 4 lower body and 2 upper body resistance exercises

  5. Change in arterial compliance [ Time Frame: pre and post 8 month interventon ]
    Arterial compliance of the large and small arteries was assessed using Pulse Contour analysis.

  6. Change in Insulin-like Growth Factor-1 (IGF-I) and Insulin-like Growth Factor BP3 (IGFBP3) [ Time Frame: pre and post 8 month intervention ]

Secondary Outcome Measures :
  1. Daily Calcium intake [ Time Frame: pre and post 8 month intervention ]
    Calcium intake is a potential confounding variable. Participants were encouraged to increase their calcium intakes if found to be low before the intervention began.

  2. Menstrual History [ Time Frame: pre and post 8 month intervention ]
    This information was used to monitor menstrual characteristics to ensure they were still premenopausal at the post test.

  3. Dietary intake [ Time Frame: At baseline at the same time as other outcomes, about 2 weeks before the beginning of the yoga training ]
    Three day dietary logs were recorded by participants before the exercise intervention. They were analyzed for caloric intake and nutrient composition using the Diet Analysis Plus 9 software.

  4. Change in physical activity levels [ Time Frame: pre and post 8 month intervention ]
    Physical activity levels estimated by the bone-specific physical activity (PA) questionnaire to monitor their PA outside of the intervention

  5. Change in body composition [ Time Frame: pre and post 8 month intervention ]


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Ages Eligible for Study:   35 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • participants had not been engaged in resistance training or in Yoga exercise for at least 12 months prior to the study
  • did not have chronic back or joint problems or cardiovascular disease
  • not taking antihypertensive drugs or any medication that affects bone density
  • not taking hormonal contraception
  • they self-reported having regular menstrual cycles.

Exclusion Criteria:

  • body weight more than 300 pounds

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02163668


Locations
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United States, Oklahoma
Department of Health and Exercise Science, University of Oklahoma
Norman, Oklahoma, United States, 73019
Sponsors and Collaborators
University of Oklahoma
Investigators
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Principal Investigator: Debra A Bemben, PhD Department of Health and Exercise Science, University of Oklahoma
Publications:
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Responsible Party: Debra Bemben, Professor, University of Oklahoma
ClinicalTrials.gov Identifier: NCT02163668    
Other Study ID Numbers: OUYogaStudy
First Posted: June 16, 2014    Key Record Dates
Last Update Posted: June 16, 2014
Last Verified: June 2014
Keywords provided by Debra Bemben, University of Oklahoma:
Yoga
Bone turnover markers
Bone strength
Bone mineral density
Additional relevant MeSH terms:
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Osteoporosis
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases
Metabolic Diseases