3D Multi-Contrast Atherosclerosis Characterization of the Carotid Artery
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|ClinicalTrials.gov Identifier: NCT02163408|
Recruitment Status : Recruiting
First Posted : June 13, 2014
Last Update Posted : July 16, 2020
|Condition or disease||Intervention/treatment|
|Carotid Artery Disease||Other: MRI with/without contrast|
|Study Type :||Observational|
|Estimated Enrollment :||140 participants|
|Official Title:||3D Multi-Contrast Atherosclerosis Characterization of the Carotid Artery|
|Actual Study Start Date :||June 24, 2014|
|Estimated Primary Completion Date :||June 2022|
|Estimated Study Completion Date :||June 2022|
100 healthy volunteers will take MRI with/without contrast using both conventional protocol and our developed protocol. Image quality and image contrast will be compared between the two protocols.
Other: MRI with/without contrast
Bilateral carotid plaque imaging at 3.0T. Conventional MRI scans with T1-, T2-weightings and scans using the developed techniques. MR contrast may be used in conventional protocol when it is needed to evaluate the performance of the developed techniques
Patients with Carotid Artery Disease
40 patients will take MRI with/without contrast using both conventional protocol and our developed protocol. Image quality, image contrast, and composition analysis will be compared between the protocols.
- Image quality score [ Time Frame: Within one year of scans ]Images collected from both investigational MRI pulse sequences and conventional protocol will be reviewed and scored by readers and compared.
- Adverse plaque characteristics detection [ Time Frame: Within one year of scans ]In patient study, the analysis of adverse plaque characteristics will be performed and compared between the conventional protocol and developed protocol.
- Image contrast-to-noise ratio [ Time Frame: Within one year of scans ]Contrast-to-noise ratio will be measured on the images collected with the conventional protocol and developed protocol and compared.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02163408
|Contact: Johanna Kim, MPH||310 email@example.com|
|United States, California|
|Cedars-Sinai Medical Center||Recruiting|
|Los Angeles, California, United States, 90048|
|Sub-Investigator: Zhaoyang Fan, PhD|
|Principal Investigator:||Debiao Li, PhD||Cedars-Sinai Medical Center|