Working…
COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC: https://www.coronavirus.gov.

Get the latest research information from NIH: https://www.nih.gov/coronavirus.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Oxygen Consumption in Critical Illness

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02163109
Recruitment Status : Unknown
Verified May 2018 by University of Oxford.
Recruitment status was:  Recruiting
First Posted : June 13, 2014
Last Update Posted : May 8, 2018
Sponsor:
Collaborator:
National Institute for Health Research, United Kingdom
Information provided by (Responsible Party):
University of Oxford

Brief Summary:

Many serious illnesses are characterised by a lack of oxygen delivery to the body's tissues. This can be due to problems with the circulation, such as when the heart fails to pump blood efficiently or if the blood pressure is very low, or due to changes in the lungs preventing them from transferring oxygen effectively from the air into the blood.

Many of the treatments used in critically ill patients are aimed at improving the supply of oxygen-rich blood to the tissues. These include drugs to increase the blood pressure or make the heart pump more forcibly, blood transfusions to increase the amount of oxygen that the blood can carry, and ventilators (breathing machines) to help the lungs introduce more oxygen into the bloodstream. Decisions to use such treatments are based on a number of factors. One of the most important is an assessment of how much oxygen an individual patient is using at a given time. Whilst it is possible to measure average oxygen consumption over a long period of time in healthy individuals, the equipment and techniques needed are simply not practical for routine use in the clinical setting of a critical care unit. Critical care doctors and nurses therefore have to rely on a number of different indicators of the adequacy of the amount of oxygen that is being provided in order to make decisions about how best to treat patients. Unfortunately, all of these have their limitations, are affected by other treatments patients may be receiving, and can be difficult to interpret. Examples include 'mixed venous oxygen saturation' (SvO2), that is the amount of oxygen in the blood coming back to the lungs from the body, ready to have more oxygen added, and blood lactate levels, which give an indication of whether the tissues have enough oxygen to produce the energy they need to function in an efficient manner.

Our group has developed a device which can be added easily to the normal equipment used on a critical care ward when a patient is on a ventilator, which can accurately and rapidly measure the amount of oxygen the individual is consuming.

This study will provide us with data so the investigators can define a "normal" range of oxygen consumption in these patients, and treatments which alter consumption. In a future study, once the investigators know what the normal range is, they can introduce new techniques to improve oxygen consumption in those patients whose consumption is less than ideal.


Condition or disease
Critical Illness

Detailed Description:

This is a prospective longitudinal observational study in thirty intubated, ventilated patients. Patients will be recruited from the population of already intubated and ventilated individuals on an adult intensive care unit (AICU). Once patients have been recruited we will insert the optical gas analyser (OGA) into the ventilation circuit (tubing) for 48 hours.

Data will be continuously collected until 48 hours from attachment of the OGA, death or extubation of the patient, and analysed retrospectively. A time series describing oxygen consumption with a resolution of one minute or less will be prepared and standard measures of dispersion calculated. In addition, variables that are routinely recorded on the computerised clinical record during the same period will then be examined and associations sought between these variables and changes in oxygen consumption as measured with the OGA. We have prospectively identified variables which, based on the published literature, are likely to be associated with variation in oxygen consumption (VO2) upon which attention will focus, though others may become apparent during the study:

  • Body temperature
  • Seizures
  • Change in haemoglobin concentration (including due to blood transfusion)
  • Bolus fluids
  • Vasoactive drugs
  • Beta-agonist drugs
  • Drugs affecting the angiotensin-converting enzyme system
  • Renal replacement therapy
  • Feeding
  • Sedation
  • Neuromuscular blockers
  • Mode of ventilation
  • Fraction of inspired oxygen (FiO2)
  • Physical activity
  • Surgery

Layout table for study information
Study Type : Observational
Estimated Enrollment : 30 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Measurement of Oxygen Consumption in Critical Illness Using Optical Gas Analysis
Actual Study Start Date : September 2015
Estimated Primary Completion Date : March 2019
Estimated Study Completion Date : March 2020

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Oxygen Therapy

Group/Cohort
Critically-ill patients
Adult patients requiring intubation and mechanical ventilation on an intensive care unit, predicted to require a further 48 hours of artificial ventilation



Primary Outcome Measures :
  1. Oxygen consumption [ Time Frame: Up to 48 hours ]
    Within patient oxygen consumption over time correlated with changes in physiological variables and treatment received



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Adult patients requiring intubation and mechanical ventilation on an adult intensive care unit
Criteria

Inclusion Criteria:

  • Male and female patients aged 18 years or over
  • Admitted to an adult intensive care unit
  • Expected duration of intubation and mechanical ventilation of at least 48 hours

Exclusion Criteria:

  • Consultee indicates patient would be likely to decline enrolment
  • Patient is receiving palliative care
  • Use of active cooling
  • Heavy sputum production (or other indication) necessitating use of an active humidifier in ventilator circuit

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02163109


Contacts
Layout table for location contacts
Contact: John D Young, DM 01865220621 duncan.young@nda.ox.ac.uk
Contact: Matthew C Frise, BMBCh 01865282357 matthew.frise@dpag.ox.ac.uk

Locations
Layout table for location information
United Kingdom
Oxford Univerity Hospital NHS Trust, John Radcliffe Hospital Recruiting
Oxford, Oxfordshire, United Kingdom, OX3 9DU
Contact: John D Young, DM    01865220621    duncan.young@nda.ox.ac.uk   
Contact: Matthew C Frise, BMBCh    01865282357    matthew.frise@dpag.ox.ac.uk   
Sub-Investigator: Matthew C Frise, BMBCh         
Principal Investigator: John D Young, DM         
Sponsors and Collaborators
University of Oxford
National Institute for Health Research, United Kingdom
Investigators
Layout table for investigator information
Principal Investigator: John D Young, DM University of Oxford and Oxford University Hospitals NHS Trust
Publications:
Layout table for additonal information
Responsible Party: University of Oxford
ClinicalTrials.gov Identifier: NCT02163109    
Other Study ID Numbers: 14/EE/0003
First Posted: June 13, 2014    Key Record Dates
Last Update Posted: May 8, 2018
Last Verified: May 2018
Keywords provided by University of Oxford:
Oxygen consumption
Pulmonary gas exchange
Cardiac output
Additional relevant MeSH terms:
Layout table for MeSH terms
Critical Illness
Disease Attributes
Pathologic Processes