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Dietary Nitrate Supplementation and Crossfit Athletes

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ClinicalTrials.gov Identifier: NCT02162927
Recruitment Status : Completed
First Posted : June 13, 2014
Last Update Posted : March 4, 2015
Sponsor:
Information provided by (Responsible Party):
Michael J. Ormsbee, Florida State University

Brief Summary:

In the past, dietary nitrate supplementation has been shown to have clinical benefits in the treatment of cardiovascular issues. More recently, however, the focus of nitrate supplementation has shifted to focus of human performance, and has shown to increase the time to exhaustion during maximal intensity exercise and lower the cost of oxygen consumption during submaximal intensity exercise. Acutely, nitrate supplementation in the form of beetroot juice has been shown to increase strength measurements, as well as increase the time to complete a 2000 meter rowing ergometer test. However, to the author's knowledge, there are no studies that link the relationship between multi-day nitrate supplementation and the rowing test or the nitrate's effect on strength when in the salt form. Additionally, to the author's knowledge, no evidence has been published which relates dietary nitrate supplementation and its effects on a CrossFit circuit workout.

Our central hypothesis is that six days of dietary nitrate supplementation will improve strength, endurance, a power more than a placebo in male CrossFit athletes.


Condition or disease Intervention/treatment Phase
Performance Dietary Supplement: Dietary Nitrate Dietary Supplement: Potassium Chloride (placebo) Not Applicable

Detailed Description:

The purpose of this randomized, double-blind, crossover study is to identify if dietary nitrate supplementation improves strength , endurance, and power measurements in male CrossFit athletes. Specifically, the strength measurements will be taken using isometric and isokinetic tests on the Biodex dynamometer. Endurance will be measured using time trials for a 2000 meter rowing test and the "Fran" CrossFit workout. Finally, power will be analyzed using the Wingate cycle test.

The treatment group will receive 1 serving of f potassium nitrate KNO3- (N) (8 mmols NO3-). The placebo group will receive 1 serving of the nitrate-free placebo (PL) potassium chloride (8 mmol KCl).

The participants will complete two three-day baseline testing, with a six-day supplementation period following each round of baseline testing. Following the first six-day supplementation period, there will be a 10 day washout period before the second baseline testing begins.


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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: The Effects of Six-day Dietary Nitrate Supplementation on Strength and Endurance Measurements in Male CrossFit Athletes
Study Start Date : August 2014
Actual Primary Completion Date : October 2014
Actual Study Completion Date : November 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Potassium

Arm Intervention/treatment
Experimental: Potassium Nitrate (N)
This involves 1 serving (2 pills) of potassium nitrate KNO3- (N) (8 mmols NO3-). The supplementation period is six days. This pill must be taken on an empty stomach (2-3 hours after eating) and must be taken about 2-3 hours before exercise.
Dietary Supplement: Dietary Nitrate
This pill must be taken on an empty stomach (2-3 hours after eating) and must be taken about 2-3 hours before exercise.

Placebo Comparator: Potassium Chloride
This involves 1 serving (2 pills) of the nitrate-free placebo (PL) potassium chloride (8 mmol KCl) for a six-day supplementation period. This pill must be taken on an empty stomach (2-3 hours after eating) and must be taken about 2-3 hours before exercise.
Dietary Supplement: Potassium Chloride (placebo)
This pill must be taken on an empty stomach (2-3 hours after eating) and must be taken about 2-3 hours before exercise.




Primary Outcome Measures :
  1. Muscular Strength [ Time Frame: During 1 month of study ]
    Muscular Strength will be tested using the isometric and isokinetic strength tests.

  2. Muscular Endurance [ Time Frame: 1 month ]
    Endurance will be tested using the 2000 meter rowing ergometer test and CrossFit circuit known as "Fran".

  3. Muscular Power [ Time Frame: 1 month ]
    Power will be measured using the Wingate cycle test.



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Ages Eligible for Study:   20 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • College-aged male CrossFit between the ages of 20 and 35 years (yr), a peak maximum oxygen uptake (VO2peak) of at least 50 ml/kg/min will be recruited to participate in this study.

Exclusion Criteria:

  • Having any thyroid and/or kidney diseases that could affect NO synthesis and/or metabolism, any illness, smoking, taking other medications, injured, not well-trained (as noted by the VO2peak), consuming any other supplements at the time of the study except protein or multivitamin, allergic to any component of the supplement, including tree nuts, in case of potential packaging mixing and contamination. Women and children as well are excluded.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02162927


Locations
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United States, Florida
CrossFit Blackbox
Tallahassee, Florida, United States, 32301
Florida State University
Tallahassee, Florida, United States
Sponsors and Collaborators
Florida State University
Investigators
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Principal Investigator: Michael Ormsbee, PhD Florida State University
Study Director: Samuel J Kramer, BS Florida State University

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Responsible Party: Michael J. Ormsbee, Assistant Professor, Florida State University
ClinicalTrials.gov Identifier: NCT02162927     History of Changes
Other Study ID Numbers: HSC2014
First Posted: June 13, 2014    Key Record Dates
Last Update Posted: March 4, 2015
Last Verified: March 2015
Keywords provided by Michael J. Ormsbee, Florida State University:
muscular strength
muscular endurance
muscular power
rowing
CrossFit
dietary nitrate