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Effects of Images Following Long-term Aerobic Exercise on Brain Activation (E-Mech Anc II)

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ClinicalTrials.gov Identifier: NCT02162524
Recruitment Status : Withdrawn
First Posted : June 12, 2014
Last Update Posted : January 11, 2016
Sponsor:
Information provided by (Responsible Party):
John Apolzan, Pennington Biomedical Research Center

Brief Summary:

The primary purpose of this study is to quantify activation of regions of the brain associated with appetite and reward after viewing high sugar and high fat (HS/HF) images compared to control images following long-term aerobic exercise.

  1. After long-term aerobic exercise compared to a no-exercise control group, viewing HS/HF food images vs. control images will result in higher activation of regions of the brain associate with appetite (hypothalamus).
  2. After long-term aerobic exercise compared to a no-exercise control group consumption of a sucrose solution compared to an artificially sweetened solution and a tasteless solution, viewing HS/HF food images vs. control images will result in lower activation of regions of the brain associated with reward [amygdala, anterior cingulate cortex (ACC), Orbitalfrontal Cortex (OFC), and ventral tegmental area (VTA), striatum, insula] in overweight and obese men and women.

Exploratory Aims As exploratory aims, investigators will test a preliminary brain connectivity analysis.


Condition or disease Intervention/treatment Phase
Obesity Behavioral: Aerobic Exercise Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 0 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Effects of Images Following Long-term Aerobic Exercise on Brain Activation (E-Mechanic Ancillary II)
Study Start Date : January 2014
Estimated Primary Completion Date : July 2015
Estimated Study Completion Date : July 2015

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
No Intervention: No Exercise Control
Healthy Living Group
Active Comparator: Aerobic Exercise Group
Persons are aerobically exercising.
Behavioral: Aerobic Exercise
The exercise groups will be closely monitored during exercise sessions for six months in our exercise-training laboratory. The intensity will be 65% VO2peak and all exercise will occur on a treadmill. One exercise group will obtain 8 KKW (kcal/kg/week) over 3-4 sessions per week, which will result in each session lasting approximately 30 minutes. The other exercise group will obtain 20 KKW, performing 4-5 sessions per week for approximately 50-70 minutes per session. These groups are combined for this ancillary study.
Other Names:
  • 8KKW
  • 20KKW




Primary Outcome Measures :
  1. fMRI [ Time Frame: baseline and post (6 month intervention) ]
    fMRI will be performed using a General Electric Signa Excite HDxT 3.0T scanner (Milwaukee, WI) approximately 10 minutes post beverage ingestion. The field of view is 24-28 cm. The scanner is equipped with functional components from GE. Supplemental components include a projection system and eye imaging system from Avotec , Inc. An eight channel head coil will be utilized for all fMRI scans, and E-prime® software will be utilized for computerized experiment design, data collection, and analysis. Visual food and control cues will be presented in a mixed event block design with blocks of HS/HF and control images. Food cues consist of full-color pictures displaying foods within a category (HS/HF). One food item will be shown in each picture. Control cues consist of scrambled images that match the food cues in color intensity and frequency. Each block is 30s in length and 6 images are presented anywhere from 3-7seconds. Total task time will be ~30 minutes.



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Male or Female
  • 18-65 years old (inclusive)
  • Weigh less than 350 lbs
  • Body mass index (BMI) between 25-43 kg/m2
  • Willing to fast for 10 hours prior to examination
  • Right handed

Exclusion Criteria:

  • Diagnosis (by self report) of diabetes
  • Diagnosis (by self report) of neurological condition
  • Current or past alcohol or drug abuse problem
  • Smoking
  • Have internal metal medical devices including cardiac pacemakers, aortic or cerebral aneurysm clips, artificial heart valves, ferromagnetic implants, shrapnel, wire sutures, joint replacements, bone or joint pins/rods/screws/clips, metal plates, metal fragments in your eye, or non-removable metal jewelry such as rings
  • Unable or unwilling to complete the imaging procedures for the duration of the MRI scan due to claustrophobia or other reason

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02162524


Locations
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United States, Louisiana
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States, 70808
Sponsors and Collaborators
Pennington Biomedical Research Center
Investigators
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Principal Investigator: John W Apolzan, PhD PBRC
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Responsible Party: John Apolzan, Postdoctoral Fellow, Pennington Biomedical Research Center
ClinicalTrials.gov Identifier: NCT02162524    
Other Study ID Numbers: PBRC 2013-045
First Posted: June 12, 2014    Key Record Dates
Last Update Posted: January 11, 2016
Last Verified: January 2016
Keywords provided by John Apolzan, Pennington Biomedical Research Center:
aerobic exercise
obesity
energy balance
Additional relevant MeSH terms:
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Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight