Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance
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|ClinicalTrials.gov Identifier: NCT02161471|
Recruitment Status : Active, not recruiting
First Posted : June 11, 2014
Last Update Posted : July 12, 2019
|Condition or disease|
|Coarctation of the Aorta Tetralogy of Fallot Transposition of the Great Arteries|
Atrial function is important for good ventricular filling and function. In patients with impaired cardiac function, atrial contraction is even more important. So far, the size and function of the atria have been assessed two-dimensionally by angiography and by echocardiography. However, these do not allow exact characterization of the volumetric changes of the atria during the cardiac cycle. Recently, cardiac magnetic resonance (CMR) has been used to assess size and function of the left atrium in adults. Little data are available about function and volume of the atria in children and the role of the atria in congenital heart disease (CHD).
The study will recruit patients with CHD (n=40) and normal controls (n=10). The patient group will be composed by patients suffering from the following conditions: coarctation of the aorta (n=10), tetralogy of Fallot (n=10), transposition of the great arteries after atrial switch (Senning procedure) (n=10), transposition of the great arteries after arterial switch operation (n=10).
The study consists of measurements of sizes and function of the right and the left atrium, respectively, by examining three-dimensional volume changes across the heart cycle, and of phase contrast measurements of blood flow across the valves of the heart.
|Study Type :||Observational|
|Estimated Enrollment :||50 participants|
|Official Title:||Haemodynamics and Function of the Atria in Patients With Congenital Heart Defects - Pilot Study by Cardiovascular Magnetic Resonance|
|Study Start Date :||October 2009|
|Estimated Primary Completion Date :||November 2020|
|Estimated Study Completion Date :||December 2020|
Patients after repair of coarctation of the aorta
Tetralogy of Fallot
Patients after repair of tetralogy of Fallot
TGA atrial switch
Patients with transposition of the great arteries after atrial switch (Senning procedure)
TGA arterial switch
Patients with transposition of the great arteries after arterial switch operation
- Right and left atrial volume [ Time Frame: Day of CMR (baseline only, no intervention) ]Measurement of maximal volume (at end of systole), volume before atrial contraction (in late diastole), and minimal volume (at end of diastole) of both atria.
- Blood flow across the atrio-ventricular valves [ Time Frame: Day of CMR (baseline only, no intervention) ]Phase contrast measurement of blood flow across the atrio-ventricular and the ventriculo-arterial valves, respectively, to serve as an internal validation of total atrial emptying volumes, as well as to contribute maximum early and late diastolic velocities.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02161471
|University Children's Hospital Zürich, Switzerland|
|Zürich, ZH, Switzerland, 8032|
|Principal Investigator:||Emanuela R Valsangiacomo Buechel, Prof.||University Children's Hospital Zürich, Switzerland|