Cognitive vs. Emotional Psychopharmacological Manipulations of Fear vs. Anxiety
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02153944|
Recruitment Status : Recruiting
First Posted : June 3, 2014
Last Update Posted : December 13, 2019
Stress and anxiety can interfere with how well people perform tasks. But performing a task can sometimes lessen anxiety by distracting people from the stress. Researchers want to examine the interaction between attention and stress. They will use two drugs with different effects on stress and concentration.
- To better understand how thinking and emotion affect anxiety and performance. Also, to study the effects of methylphenidate and propranolol on performance.
- Adults age 18 50.
- First, participants will be screened with a test in which they hear loud, sudden noises through headphones. Sticky pad electrodes will be placed on the skin under one eye. These electrodes will tell us how sensitive participants are to the noises.
- Second, participants will complete questionnaires about their mood, thinking, and anxiety. They will give a saliva sample. For this, a cotton swab will be placed in their mouth for 2 minutes.
- Third, participants will take a single dose of one of the study pills or a placebo. They will then look at words, shapes, and letters on a computer monitor. They will answer questions about what they remember. They may receive a shock or hear loud noises during the tests.
- For the shocks, small metal disk or sticky pad electrodes will be taped to a wrist or finger. For recording bodily responses, additional electrodes will be placed on the arms, body, and under each eye.
- Blood pressure and pulse will be measured during the tests. More saliva samples will be taken.
- At the end of the study, participants will answer questions about their reaction to the study testing and about any effects they noticed from the study pill.
- After the experiment, participants will be evaluated for effects of the study pill.
|Condition or disease||Intervention/treatment||Phase|
|Anxiety Disorder||Drug: Propanolol Drug: Methylphenidate||Not Applicable|
Show Detailed Description
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||300 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Primary Purpose:||Basic Science|
|Official Title:||Cognitive vs. Emotional Psycho-Pharmacological Manipulations of Fear vs. Anxiety|
|Actual Study Start Date :||June 16, 2014|
|Estimated Primary Completion Date :||February 6, 2021|
|Estimated Study Completion Date :||August 6, 2021|
60mg during study visit
Placebo Comparator: 2
placebo to be given during study visit
- 1.) Will the reduction of induced-anxiety with propranolol improve cognitive performance. 2.) Will the facilitation of cognitive performance with methylphenidate reduce induced-anxiety. [ Time Frame: End of study ]Startle response
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02153944
|Contact: Monique Ernst, M.D.||(301) email@example.com|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 firstname.lastname@example.org|
|Principal Investigator:||Monique Ernst, M.D.||National Institute of Mental Health (NIMH)|