Dynamic Gait Analysis in Children With Mucopolysaccharidosis Type IVa
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|ClinicalTrials.gov Identifier: NCT02153255|
Recruitment Status : Withdrawn (Closure of Gait Analysis Laboratory - unable to set up alternative gait laboratory in time for funders)
First Posted : June 3, 2014
Last Update Posted : July 28, 2016
Mucopolysaccharidosis Type IVa (MPS IVa, Morquio Disease) is a rare inherited lysosomal storage disorder caused by deficiency of the enzyme galactose-6-sulfatase.
Children with this disease accumulate a chemical called keratan sulphate, which stops their skeletons developing properly. They are very short in stature and many of their joints are unstable. Children with MPS IVa walk in a different way to other people due to a combination of lax ligaments and skeletal problems such as knock-knees.
Human walking involves the coordinated movements of all four limbs. As we walk, the arms swing oppositely to the legs. This movement pattern is very different in children with MPS IVa. This change seems to involve the whole musculoskeletal system and depends on the severity of the disease.
Recent studies in children with MPS IVa describing walking pattern have concentrated solely on the lower or upper limb respectively, and have not looked at the interaction of the upper and lower limbs during walking.
To our knowledge, the mechanics of walking in children with MPS IVa has not been investigated using a dynamic gait analysis tool (using cameras, sensors and electrodes to track the movements of different parts of the body during walking) and we aim to characterise this in a small number of children with MPS IVa and also examine the effects of splinting the wrist upon the walking pattern to see if this simple intervention makes it easier or more difficult for children with MPS IVa to walk.
|Condition or disease|
|Mucopolysaccharidosis IV Morquio A Disease|
|Study Type :||Observational|
|Actual Enrollment :||0 participants|
|Study Start Date :||July 2016|
|Actual Primary Completion Date :||July 2016|
|Actual Study Completion Date :||July 2016|
|Children With Mucopolysaccharidosis Type IVa|
- Evidence of abnormal walking pattern and surface EMG activity as assessed by Dynamic Gait Analysis [ Time Frame: Within 6 months of recruitment ]Assessment of head, trunk and joint positions during walking using a 12 camera Vicon motion analysis system. Surface EMG analysis using a 16 channel wireless surface electromyographic (sEMG) system. Assessment of lower limb joint moments and powers using Kistler 9281 and AMTI OPT 400600 force plates.
- Change in gait pattern over one year [ Time Frame: 12 months after first analysis ]Comparison of two gait analysis studies taken 12 months apart
- Effect on gait pattern of using wrist splints [ Time Frame: Within 6 months of recruitment ]Assessment of repeat gait analysis measurements done at first visit whilst wearing wrist splints
- Effect on gait pattern of lower limb surgery [ Time Frame: Within 3 and 6 months of any lower limb surgery ]Further gait analysis studies will be done if a child undergoes any lower limb orthopaedic surgery during the study period and compared with pre-surgery analyses
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02153255
|Birmingham Children's Hospital NHS Foundation Trust|
|Birmingham, West Midlands, United Kingdom, B4 6NH|