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The Implementation of Novel 'Heavy' Water Techniques for Determining Modulation of Muscle Protein, DNA and Lipid Synthesis Due to Ageing

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ClinicalTrials.gov Identifier: NCT02152839
Recruitment Status : Completed
First Posted : June 2, 2014
Last Update Posted : July 31, 2015
Sponsor:
Collaborator:
Physiological Society
Information provided by (Responsible Party):
University of Nottingham

Brief Summary:
Maintenance of body's skeletal muscle is key to a healthy older age. However, as we age we lose on average 1-2% of our muscle each year. In order to slow this loss we need to understand fully the mechanisms regulating muscle mass with ageing. In this project we aim to determine these mechanisms using a new novel technique of 'heavy' water ingestion, which will allow us to measure multiple aspects of skeletal muscle mass control during normal everyday activities in young and old individuals over a period of 6 weeks. We will also determine the influence of resistance exercise training during this period in offsetting declines in muscle with ageing using this method

Condition or disease Intervention/treatment Phase
Healthy Behavioral: Resistance Exercise Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Study Start Date : May 2013
Actual Primary Completion Date : July 2014

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Old Unilateral Exercise
Old individuals (65-75y) studied before and after 6 weeks of unilateral resistance exercise training
Behavioral: Resistance Exercise
6 Weeks progressive unilateral resistance exercise, 3 times per week, 70% 1-RM, 6 x 8 Repetitions. 2 minutes rest between sets

Experimental: Young Unilateral Exercise
Young Individuals (18-30y) studied before and after 6 weeks unilateral resistance exercise training
Behavioral: Resistance Exercise
6 Weeks progressive unilateral resistance exercise, 3 times per week, 70% 1-RM, 6 x 8 Repetitions. 2 minutes rest between sets




Primary Outcome Measures :
  1. Muscle Protein Synthesis [ Time Frame: 0-6 Weeks ]
    Comparison of muscle protein synthesis between young and older individuals and in response to 6 weeks unilateral exercise training


Secondary Outcome Measures :
  1. Muscle Sub fractions [ Time Frame: 0-6 week ]
    Comparison of different sub fractions involved in muscle mass regulation between young and older individuals and in response unilateral exercise training


Other Outcome Measures:
  1. Muscle Functions [ Time Frame: 0-6 Weeks ]
    Muscle Strength and power un young and older individuals in response to unilateral exercise training



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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Young (18-30y) and old men (65-75y) who are generally healthy and recreationally active

Exclusion Criteria:

  • Active cardiovascular disease
  • Cerebrovascular disease including previous stroke, aneurysm (large vessel or intracranial)
  • Respiratory disease including pulmonary hypertension or COPD
  • Hyper/ hypo parathyroidism, hyper/ hypothyroidism, Cushing's disease, diabetes
  • Active inflammatory bowel disease
  • Renal disease
  • Malignancy
  • Recent steroid treatment (within 6 mo), or hormone replacement therapy
  • Clotting dysfunction
  • Musculoskeletal or neurological disorders
  • Any disease requiring long-term drug prescriptions, including statins

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02152839


Locations
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United Kingdom
Royal Derby Hospital Medical School
Derby, United Kingdom, DE22 3DT
Sponsors and Collaborators
University of Nottingham
Physiological Society
Investigators
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Principal Investigator: Philip Atherton, PhD, AFHEA University of Nottingham

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Responsible Party: University of Nottingham
ClinicalTrials.gov Identifier: NCT02152839     History of Changes
Other Study ID Numbers: Physoc_D20
First Posted: June 2, 2014    Key Record Dates
Last Update Posted: July 31, 2015
Last Verified: July 2015