Cerebral Blood Flow During Flexion and Rotation of the Cervical Spine (TCDPOS)
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|ClinicalTrials.gov Identifier: NCT02152488|
Recruitment Status : Completed
First Posted : June 2, 2014
Last Update Posted : June 2, 2014
Rotation or flexion of the cervical spine is unavoidable during positioning for some surgical procedures as carotid endarterectomy, thyroidectomy and surgery of the shoulder. Rotation or flexion may reduce blood flow in the carotid or vertebral arteries and induce intraoperative cerebral ischemia with impact on the neurological outcome of surgery. Predominantly if the circulus willisii is incomplete because of congenital variation, collateral arteries may not be sufficient to compensate reduced blood flow in one carotid or vertebral artery. This may be aggravated by intraoperative hypotension in limits tolerable under normal conditions but fatal during impairment of vascular conductivity by positioning. The middle cerebral artery (MCA) is a final large scale pathway of cerebral blood flow and hence relevant reduction of flow in the MCA may serve as a surrogate parameter for relevant reduction of cerebral blood flow caused by carotid stretching or narrowing.
Objective of this study is to investigate, if MCA blood flow in normal male and female subjects, aged 18 to 85 years, is reduced in extended and rotated cervical spine position in comparison to neutral position.
|Condition or disease|
|Functional Blood Flow Disorder|
|Study Type :||Observational|
|Actual Enrollment :||80 participants|
|Official Title:||Cerebral Blood Flow During Flexion and Rotation of the Cervical Spine|
|Study Start Date :||March 2010|
|Actual Primary Completion Date :||April 2010|
|Actual Study Completion Date :||April 2010|
- Blood flow in middle cerebral artery during rotation of the cervical spine [ Time Frame: From measurement of baseline blood flow until measurement of blood flow during rotation to the right and hyperextension of the cervical spine up to 1 hour ]Blood flow in the middle cerebral artery (MCA) was measured bilaterally using a bidirectional multigate 2Mhz pulsed wave Transcranial Doppler in normal and rotated position of the cervical spine.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02152488
|University Hospital Schleswig-Holstein, Campus Kiel|
|Kiel, Schleswig-Holstein, Germany, 24105|
|Principal Investigator:||Axel Fudickar, Dr.||University Hospital Schleswig-Holstein, Campus Kiel|