Hemodynamic Repercussions of Noninvasive Ventilation
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|ClinicalTrials.gov Identifier: NCT02139631|
Recruitment Status : Completed
First Posted : May 15, 2014
Last Update Posted : September 15, 2015
The noninvasive ventilation (NIV) is a method of ventilatory support that does not require artificial airway. Its application is associated with complex hemodynamic repercussions, therefore is important to identify them for safety and effectiveness of the technique application.
The main objective of this research is to evaluate the hemodynamic repercussions using doppler echocardiography in healthy volunteers submitted a different values of positive end expiratory pressure (PEEP) by the following ventilatory modes: Continuous positive airway pressure (CPAP) and Bilevel.
The study hypothesis is that the positive end expiratory pressure (PEEP) may cause hemodynamic repercussions as: reduction of the ventricles pre-load, left ventricle after load, cardiac output and reduction in the diameter of the superior vena cava, due to the increase in the intrathoracic pressure and pulmonary volumes.
|Condition or disease||Intervention/treatment||Phase|
|Haemodynamic Rebound||Other: Noninvasive ventilation||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||30 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||Double (Participant, Investigator)|
|Primary Purpose:||Basic Science|
|Official Title:||Evaluation of the Hemodynamic Repercussions of Non Invasive Ventilation in Healthy Individuals by Doppler Echocardiography|
|Study Start Date :||May 2014|
|Actual Primary Completion Date :||November 2014|
|Actual Study Completion Date :||November 2014|
Experimental: Healthy volunteers
The volunteers initially underwent a clinical examination, spirometry and echocardiography to prove the health state. Then, different levels of positive end expiratory pressure (PEEP) is applied by the noninvasive ventilation in all individuals and the hemodynamic repercussions are evaluated by the doppler echocardiography
Other: Noninvasive ventilation
Assess the hemodynamic repercussions of the positive end expiratory pressure applied noninvasively
- Hemodynamic repercussions of different levels of positive end expiratory pressure applied noninvasively, measured by echocardiography [ Time Frame: 5 minutes ]The hemodynamic variables evaluated are: ventricular preload, left ventricle afterload, cardiac output, blood pressure and the vena cava's diameter. All variables will be assessed by echocardiography
- Measurement of cardiac output as a predictor of cardiopulmonary adaptation to different pressures. [ Time Frame: 5 minutes ]
- Difference between the hemodynamic effects generated by ventilation modes CPAP and Bilevel [ Time Frame: 3 hours ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02139631
|Federal University of Uberlandia|
|Uberlandia, Minas Gerais, Brazil|
|Principal Investigator:||Celia R Lopes||Federal University of Uberlandia|