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A Cardiac Ultrasound Evaluation of Two Types of Weaning Trials of Mechanical Ventilation for a First Weaning Trial (CARWEAN)

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ClinicalTrials.gov Identifier: NCT02138903
Recruitment Status : Completed
First Posted : May 15, 2014
Last Update Posted : December 2, 2014
Sponsor:
Information provided by (Responsible Party):
University Hospital, Clermont-Ferrand

Brief Summary:
Comparing the hemodynamic and cardiac effects of two types of weaning trials of mechanical ventilation in ICU patients of two French ICU.

Condition or disease Intervention/treatment
Critical Care Weaning of Mechanical Ventilation Trans-thoracic Echocardiography Mitral Doppler Diastolic Function Other: trans thoracic echocardiography

Detailed Description:
Prospective clinical study in ICU with ventilated patients eligible to weaning trials of mechanical ventilation (ZEEP and tubing-spontaneous ventilation) comparing hemodynamic and cardiac effects evaluated by trans-thoracic echocardiography.

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Study Type : Observational
Actual Enrollment : 120 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: A Cardiac Ultrasound Evaluation of Two Types of Weaning Trials of Mechanical Ventilation for a First Weaning Trial
Study Start Date : January 2014
Actual Primary Completion Date : November 2014
Actual Study Completion Date : November 2014

Group/Cohort Intervention/treatment
ZEEP and tubing-spontaneous ventilation
Prospective clinical study in ICU with ventilated patients eligible to weaning trials of mechanical ventilation (ZEEP and tubing-spontaneous ventilation) comparing hemodynamic and cardiac effects evaluated by trans-thoracic echocardiography.
Other: trans thoracic echocardiography
trans-thoracic echocardiography
Prospective clinical study in ICU with ventilated patients eligible to weaning trials of mechanical ventilation (ZEEP and tubing-spontaneous ventilation) comparing hemodynamic and cardiac effects evaluated by trans-thoracic echocardiography.
Other: trans thoracic echocardiography



Primary Outcome Measures :
  1. left ventricular filling pressure [ Time Frame: after 1 hour ]
    Echo-cardiographic evaluation is realized at the end of the weaning trial (1 hour) or less if failed


Secondary Outcome Measures :
  1. Comparison of other echocardiographic parameters of left ventricular filling pressures [ Time Frame: after 1 hour ]
    Comparison of other echocardiographic parameters of left ventricular filling pressures (E, Ea, deceleration time) at the end of weaning trial



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
ICU patients
Criteria

Inclusion Criteria:

  • Adult patients ventilated requiring first weaning trial of mechanical ventilation

    • Stable respiratory and hemodynamic conditions
    • Consent of patients or family
    • Arterial line
    • Ventilated patients

Exclusion Criteria:

-


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02138903


Locations
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France
CHU de Clermont-Ferrand
Clermont-Ferrand, France, 63003
Sponsors and Collaborators
University Hospital, Clermont-Ferrand
Investigators
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Principal Investigator: Sébastien PERBET University Hospital, Clermont-Ferrand
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Responsible Party: University Hospital, Clermont-Ferrand
ClinicalTrials.gov Identifier: NCT02138903    
Other Study ID Numbers: CHU-189
2013-000960-26
First Posted: May 15, 2014    Key Record Dates
Last Update Posted: December 2, 2014
Last Verified: November 2014
Keywords provided by University Hospital, Clermont-Ferrand:
weaning
Cardiac
Echocardiography
Mechanical Ventilation