Capsaicinoid Ingestion, Human Metabolism and Exercise (Phase 2)
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|ClinicalTrials.gov Identifier: NCT02138630|
Recruitment Status : Unknown
Verified September 2015 by Dr. Jamie Burr, University of Prince Edward Island.
Recruitment status was: Active, not recruiting
First Posted : May 14, 2014
Last Update Posted : September 17, 2015
Capsaicinoids (the active ingredient in hot peppers) have been shown to cause a moderate increase in energy expenditure (50 kcal/day) as well as reductions in appetite, energy intake, and (visceral) adiposity. As such, there is considerable interest in capsaicinoid for weight loss supplements. Owing to the fact that these changes are believed to be driven by catecholamine release and alterations in fat oxidation, there is growing belief that capsaicin may also offer potential ergogenic benefits (performance enhancement) during exercise, similar to the affect of caffeine, which works through similar pathways. Of particular interest are the recent findings that free-fatty acids in the blood are elevated 2-2.5hrs post ingestion, yet changes in typical cardiovascular or sympathetic nervous tone indicators (heart rate, blood pressure) were unaffected, suggesting some of the negative consequences of other stimulants may be avoided. At present, however, more in depth investigations of the effects on endothelial function, vascular autonomic tone and inflammation are lacking.
Although there are some indications that capsaicinoid ingestion may alter factors associated exercise performance (such as increased fat oxidation for glucose sparing), to date these studies have primarily used very low exercise intensities wherein these effects are typically unnecessary, and results are not generalizable to the typical race intensities of endurance sport competition. Performance measures have also been a noticeably absent outcome from research to date.
Hypotheses: 1), Exercise performance will improve, at a level similar to those demonstrated for caffeine ingestion 2) ratings of perceived exertion will go down with the effect of causing intensity to go up 3) During sustained aerobic activity approaching the aerobic threshold alterations in substrate use will be minimal (but possibly meaningful in regard to performance); alterations at rest will be more pronounced. 4) acute alterations (6o min post single dose) in blood pressure, HRV, arterial stiffness and RMR will mirror the effects observed for more prolonged exposure in phase 1.
|Condition or disease||Intervention/treatment||Phase|
|Metabolism Exercise||Dietary Supplement: Capsaicin Dietary Supplement: Placebo||Early Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||15 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Outcomes Assessor)|
|Official Title:||The Physiological Effects of Capsaicinoid Ingestion on Human Metabolism and Exercise Performance|
|Study Start Date :||June 2014|
|Estimated Primary Completion Date :||January 2016|
|Estimated Study Completion Date :||January 2016|
|Placebo Comparator: Placebo||
Dietary Supplement: Placebo
Single Capsule, "Capsimax" 100 mg, ingested 60 min prior to exercise
Dietary Supplement: Capsaicin
Other Name: Capsimax
- Performance [ Time Frame: 2 to 4 hours ]Exercise: Time to exhaustion on a cycle ergometer at controlled relative intensity
- Substrate Use [ Time Frame: 2 to 4 hours ]Measurement of expired gases
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02138630
|Canada, Prince Edward Island|
|Charlottetown, Prince Edward Island, Canada, C1A4P3|