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Representation of the Bladder Innervation Using Diffusion Tensor Imaging Fiber Tracking With MRI - a Pilot Study

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ClinicalTrials.gov Identifier: NCT02138201
Recruitment Status : Completed
First Posted : May 14, 2014
Last Update Posted : November 17, 2015
Sponsor:
Information provided by (Responsible Party):
Swiss Paraplegic Centre Nottwil

Study Description
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Brief Summary:

The exact innervation of the bladder and the changes after a spinal cord injury have been not yet been illustrated.

Diffusion tensor imaging with magnetic resonance imaging is a new technique which can be used to visualize single nerve fibers, and thus represent the neural supply of a region in vivo. There are studies in which both the sacral plexus and the lumbar nerve roots have been represented using diffusion tensor imaging. However, there is no study concerning the innervation of the bladder.

The investigators are therefore using diffusion tensor imaging with magnetic resonance imaging to represent the bladder innervation of individuals with neurogenic lower urinary tract dysfunction and individuals with normal bladder function.


Condition or disease
Spinal Cord Injury Neurogenic Lower Urinary Tract Dysfunction

Study Design
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Study Type : Observational
Actual Enrollment : 10 participants
Time Perspective: Prospective
Study Start Date : January 2014
Actual Primary Completion Date : November 2015
Actual Study Completion Date : November 2015

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Groups and Cohorts
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Group/Cohort
control
individuals with normal bladder function
neurogenic bladder
individuals suffering from neurogenic lower urinary tract dysfunction


Outcome Measures
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Primary Outcome Measures :
  1. bladder innervation quality [ Time Frame: day 0 ]
    bladder innervation is illustrated using diffusion tensor imaging fiber tracking with magnetic resonance imaging


Eligibility Criteria
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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
individuals with and without neurogenic lower urinary trat dysfunction
Criteria

Inclusion Criteria:

  • neurogenic lower urinary trat dysfunction
  • normal bladder function

Exclusion Criteria:

  • no signed informed consent
  • contraindications for MRI (pace maker, implanted metal, claustrophobia)
  • upper or lower urinary tract surgeries
  • pregnancy (anamnestic)
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02138201


Locations
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Switzerland
Swiss Paraplegic Centre
Nottwil, LU, Switzerland, CH-6207
Sponsors and Collaborators
Swiss Paraplegic Centre Nottwil
More Information
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Responsible Party: Swiss Paraplegic Centre Nottwil
ClinicalTrials.gov Identifier: NCT02138201    
Other Study ID Numbers: 2013-25
First Posted: May 14, 2014    Key Record Dates
Last Update Posted: November 17, 2015
Last Verified: November 2015
Keywords provided by Swiss Paraplegic Centre Nottwil:
diffusion tensor imaging fiber tracking
magnetic resonance Imaging
spinal cord injury
neurogenic lower urinary tract dysfunction
Additional relevant MeSH terms:
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Spinal Cord Injuries
Spinal Cord Diseases
Central Nervous System Diseases
 Nervous System Diseases
Trauma, Nervous System
Wounds and Injuries