Is the Nerve Growth Factor (NGF) a Useful Biomarker in Neurogenic Bladder Dysfunction After Spinal Cord Injury?
|ClinicalTrials.gov Identifier: NCT02138149|
Recruitment Status : Completed
First Posted : May 14, 2014
Last Update Posted : November 17, 2015
Spinal cord injury (SCI) almost always affects bladder function as well. As a result of this bladder dysfunction, individuals with SCI have to undergo regular invasive examination of their bladder function (urodynamic examination).
The nerve growth factor (NGF) is released from smooth muscle cells of the bladder, and there are reports, that the concentration of NGF is elevated in the urine of patients with bladder dysfunction. The NGF concentration can also be measured in the blood. The concentration of NGF in the blood and urine of SCI individuals has not yet been investigated. These concentrations may correlate with the severity of bladder dysfunction, and may thus be used to replace or at least reduce the number of the more invasive urodynamic examinations.
The hypothesis that urine and blood NGF concentrations in individuals with SCI are higher compared to individuals with healthy bladder function will be tested.
|Condition or disease|
|Spinal Cord Injury Neurogenic Detrusor Overactivity Neurogenic Lower Urinary Tract Dysfunction|
|Study Type :||Observational|
|Actual Enrollment :||47 participants|
|Study Start Date :||November 2013|
|Actual Primary Completion Date :||November 2015|
|Actual Study Completion Date :||November 2015|
spinal cord injury
individuals with neurogenic lower urinary tract dysfunction
individuals with physiologic bladder function
- urinary concentration of nerve growth factor [ Time Frame: day 0 ]
- serum concentration of nerve growth factor [ Time Frame: day 0 ]
- demographics [ Time Frame: day 0 ]
- urodynamics [ Time Frame: day 0 ]only participants with spinal cord injury
- International Prostate Symptom Score (I-PSS) [ Time Frame: day 0 ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02138149
|Swiss Paraplegic Centre|
|Nottwil, LU, Switzerland, 6207|