The Effect of Atorvastatin on Endothelial Cell Dysfunction in Chronic Kidney Disease
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|ClinicalTrials.gov Identifier: NCT02133534|
Recruitment Status : Terminated (failure to enroll)
First Posted : May 8, 2014
Results First Posted : July 3, 2014
Last Update Posted : July 3, 2014
|Condition or disease||Intervention/treatment||Phase|
|Chronic Kidney Disease High Cholesterol||Drug: Atorvastatin||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||1 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Effect of Atorvastatin on Endothelial Cell Dysfunction in Chronic Kidney Disease|
|Study Start Date :||February 2008|
|Actual Primary Completion Date :||May 2009|
|Actual Study Completion Date :||May 2009|
Subjects will be treated with atorvastatin 10 mg/day for 30 days. The study team will obtain one blood and urine sample at baseline prior to starting atorvastatin therapy, and again after 30 days of drug therapy. The study team will do ultrasound imaging of the arm in which a probe will be placed over the blood vessels to measure the diameter of the artery and how this changes after a blood pressure cuff is inflated and then deflated. Subjects will take one nitroglycerine tablet during the ultrasound imaging.
Other Name: Lipitor
- Improved Counts of Endothelial Progenitor Cells [ Time Frame: baseline, 30 days ]Improvement of endothelial cell (EC) dysfunction will be assessed by improved counts of endothelial progenitor cells.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02133534
|Principal Investigator:||Lynda Szczech, MD||Duke University|