Metabolic Costs of Daily Activities in Older Adults (CHORES-XL)
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The work will evaluate the metabolic costs for daily activities across the lifespan and evaluate the influence of having functional impairments.
Condition or disease
The work will evaluate the metabolic costs for daily activities across the lifespan and evaluate the influence of having functional impairments. The project will simultaneously conduct a cross-sectional and a case-control study. The primary aim will investigate cross-sectional association between older age and the energy expenditure of daily activities by recruiting approximately 25 adults in each of 7 age groups (20-30,30-40,40-50,50-60,60-70,70-80,80+) for a total of 180 individuals. A secondary aim will investigate the effect of functional impairments on the energy expenditure of daily activities by conducting a case-control study. An additional 25 older adults with functional impairment will be recruited in each age decade (60-70, 70-80, and 80+ years old) to accomplish this aim. Additional outcomes will evaluate rating of perceived exertion differences in daily activities. A tertiary aim will investigate using accelerometers to predict the metabolic costs of daily activities.
MET value [ Time Frame: Participants will attend up to 4 visits within one month of enrollment to attain these data ]
MET value of physical activities defined as the oxygen uptake (VO2 = milliliter• min-1•kg-1) during a steady state rate expressed as a function 3.5 milliliter• min-1•kg-1.
Metabolic economy [ Time Frame: Participants will attend up to 4 visits within one month of enrollment to attain these data ]
Metabolic economy is the energy expended for a given work rate.
Relative metabolic cost to peak energy expenditure [ Time Frame: Participants will attend up to 4 visits within one month of enrollment to attain these data ]
Relative metabolic cost is function of peak oxygen consumption
Relative metabolic cost to resting energy expenditure [ Time Frame: Participants will attend up to 4 visits within one month of enrollment to attain these data ]
Relative metabolic cost as a function of resting
Secondary Outcome Measures :
Rating of perceived exertion [ Time Frame: Participants will attend up to 4 visits within one month of enrollment to attain these data ]
Ratings of perceived exertion will be collected during all activities. Investigators will use the Category Ratio scale-10 scale developed by Borg in 1982.
Other Outcome Measures:
Accelerometer signals to predict of energy expenditure [ Time Frame: Participants will attend up to 4 visits within one month of enrollment to attain these data ]
A tertiary outcome is to validate body worn monitors (e.g. accelerometers) to estimate the type and intensity of activity for accurate estimation of energy expenditure. A predicted metabolic equivalent value will be estimated for each activity.
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Layout table for eligibility information
Ages Eligible for Study:
20 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Community dwelling population
Age 20+ years old
Community dwelling adults without significant health issues
Willingness to undergo all testing procedures
Weight stable for at least three months
Able to understand and speak English
Failure to provide informed consent
A 10% enrollment limit will be applied to avid exercisers in each age decade. Avid exercises will be defined as doing structured exercise 3 or more days per week (e.g. jogging, sports etc., walkers will be permitted in the study). Based on our experience, avid exercisers volunteer for this type of research at a high rate and thus the investigators will limit these individuals to prevent a biased comparison
Use of walker (use of a cane is permitted)
Lower extremity amputation
Develops chest pain or severe shortness of breath during physical stress
Severe rheumatologic or orthopedic diseases, e.g., awaiting joint replacement, active inflammatory disease; self-reported severe osteoarthritis
Terminal illness, as determined by the participant
Severe pulmonary disease, requiring the use of supplemental oxygen or steroid therapy
Severe cardiac disease, including New York Heart Association Class III or IV congestive heart failure, clinically significant aortic stenosis, recent history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
Other significant comorbid disease discovered during medical screening, e.g. renal failure on hemodialysis, psychiatric disorder (e.g. bipolar, schizophrenia); chronic fatigue syndrome etc…
Liver diseases: chronic hepatitis, an inflammatory disease, or cirrhosis
Pregnancy. Participants within childbearing age will have a pregnancy test.
Contraindications to graded exercise testing according to the American Thoracic Society:
Acute myocardial infarction (<6 months since event)
Uncontrolled arrhythmias causing symptoms or hemodynamic compromise
Acute myocarditis or pericarditis
Symptomatic severe aortic stenosis
Uncontrolled heart failure
Acute pulmonary embolus or pulmonary infarction
Thrombosis of lower extremity
Suspected dissecting aneurysm
Room air desaturation at rest < 85%
Acute non cardiopulmonary disorder that may affect exercise performance