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Predictive Value of Periodic Repolarization Dynamics in Post-Infarction Patients (PRD-MI)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02128477
Recruitment Status : Completed
First Posted : May 1, 2014
Last Update Posted : January 25, 2017
Information provided by (Responsible Party):

Brief Summary:
Increased periodic repolarization dynamics (PRD) indicate increased risk of death in cardiac patients. This study thoughts to prospectively validate the prognostic value of PRD in post-infarction patients.

Condition or disease
Myocardial Infarction

Detailed Description:

Periodic repolarization dynamics (PRD) reflect periodic changes of repolarization instability located in the low-frequency spectral range. Level of PRD can be assessed using a high resolution surface ECG recorded in the 12-leads of Frank leads configuration during resting conditions.

Increased levels of PRD have been associated with sympathetic overactivity and increased risk of mortality in survivors of acute myocardial infarction and patients undergoing a clinically indicated exercise test.

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Study Type : Observational
Actual Enrollment : 754 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Predictive Value of Periodic Repolarization Dynamics in Post-Infarction Patients: Validation Study
Actual Study Start Date : October 2010
Actual Primary Completion Date : December 2016
Actual Study Completion Date : December 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Attack

Primary Outcome Measures :
  1. Number of total deaths [ Time Frame: 24 months ]

Secondary Outcome Measures :
  1. Number of cardiovascular deaths [ Time Frame: 24 months ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
myocardial infarction

Inclusion Criteria:

  • previous myocardial infarction >4 weeks
  • age >18 years

Exclusion Criteria:

  • life expectancy < 1 year due to non-cardiac causes
  • unable to give informed consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02128477

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Eberhard-Karls-University Tuebingen
Tuebingen, Baden-Württemberg, Germany, 72076
Sponsors and Collaborators
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Responsible Party: Identifier: NCT02128477    
Other Study ID Numbers: BIO012014
First Posted: May 1, 2014    Key Record Dates
Last Update Posted: January 25, 2017
Last Verified: January 2017
Keywords provided by
Myocardial infarction
Repolarization instability
Ventricular fibrillation
Additional relevant MeSH terms:
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Myocardial Infarction
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases