Skeletal Muscle Perfusion With LVAD
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|ClinicalTrials.gov Identifier: NCT02105831|
Recruitment Status : Recruiting
First Posted : April 7, 2014
Last Update Posted : August 23, 2018
Advanced heart failure (when the heart pump fails) is associated with symptoms such as shortness of breath and extreme fatigue. Some of these symptoms are simply due to failure of the pump, however abnormal regulation of blood flow to the muscles of the body is also a potential mechanism. Left ventricular assist devices are mechanical pumps used to compensate for patients with failing hearts either as a bridge to heart transplant or as long term therapy. Whether or not these pumps improve muscle flow and whether this is a determinant in the improvement of symptoms is unknown. Understanding how skeletal muscle and heart perfusion is altered in heart failure patients before and after implantation of an LVAD could provide further insight into the beneficial effects of this therapy.
- To evaluate skeletal muscle and heart perfusion studies before and after LVAD implantation
- To compare functional status with degree of skeletal muscle perfusion.
|Condition or disease||Intervention/treatment|
|Heart Failure||Other: Contrast ultrasound skeletal muscle perfusion imaging|
Thirty patients deemed to be candidates for LVAD from either outpatient heart failure clinic or inpatient cardiology service will be studies. Skeletal muscle perfusion imaging using standard of care ultrasound technology will be performed prior to LVAD implant and then 3 months post implant. Functional status by six minute walk test and specialized stress test will be assessed at 3 months post implant.
|Study Type :||Observational|
|Estimated Enrollment :||30 participants|
|Actual Study Start Date :||February 1, 2014|
|Estimated Primary Completion Date :||December 2019|
|Estimated Study Completion Date :||December 2019|
CEU skeletal muscle perfusion imaging
Heart failure with LVAD Contrast ultrasound skeletal muscle perfusion imaging
Other: Contrast ultrasound skeletal muscle perfusion imaging
1. Contrast ultrasound perfusion imaging will be performed in patients in whom LVAD will be placed for clinical indications of severe heart failure.
- Skeletal muscle perfusion on contrast enhanced ultrasound [ Time Frame: 3 months ]
Skeletal muscle perfusion will be quantified:
- Prior to LVAD placement
- 3 months post LVAD placement
- 6 minute walk test [ Time Frame: 3 month ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02105831
|Contact: Jonathan R Lindner, MD||503 firstname.lastname@example.org|
|United States, Oregon|
|Oregon Health & Science University||Recruiting|
|Portland, Oregon, United States, 97239|
|Contact: Jonathan R Lindner, MD 503-494-8750 email@example.com|
|Principal Investigator: Jonathan R Lindner, MD|