A Randomised Controlled Trial Comparing Single Shot Adductor Canal Block With Local Infiltration Analgesia for Postoperative Analgesia After Total Knee Arthroplasty
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|ClinicalTrials.gov Identifier: NCT02104934|
Recruitment Status : Completed
First Posted : April 7, 2014
Last Update Posted : April 25, 2017
Total knee arthroplasty or replacement (TKA), a commonly performed surgery for osteoarthritis of the knee, is a painful procedure and requires a multimodal analgesic approach. A method for analgesia is local infiltration analgesia (LIA), where a mixture of drugs is injected around the knee joint.
Adductor canal block (ACB) is an alternative regional anaesthesia technique which has been shown to result in minimal thigh weakness.
The investigators aim to study if the analgesia provided by ACB is superior to LIA while preserving quadriceps strength.
|Condition or disease||Intervention/treatment||Phase|
|Analgesia in Total Knee Arthroplasty||Procedure: Adductor Canal Block||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||40 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Outcomes Assessor)|
|Official Title:||A Randomised Controlled Trial Comparing Single Shot Adductor Canal Block With Local Infiltration Analgesia for Postoperative Analgesia After Total Knee Arthroplasty|
|Study Start Date :||March 2014|
|Actual Primary Completion Date :||December 2015|
|Actual Study Completion Date :||March 2016|
No Intervention: Local Infiltration Analgesia
The Local Infiltration Analgesia group will receive local infiltration of ropivacaine 150mg, ketorolac 30mg, morphine 10mg, adrenaline 200mcg and vancomycin 500mg in a total volume of 75mls by the surgeon.
Active Comparator: Adductor Canal Block
The Adductor Canal Block group of patients will receive intravenous ketorolac 30mg intra-operatively and an adductor canal block at the end of surgery. The block will be performed under real time ultrasound guidance and 30mls of 0.5% ropivacaine (150mg) is injected with a Stimuplex A100, 21G needle.
Procedure: Adductor Canal Block
- Morphine consumption in the first 24 hours [ Time Frame: 24 hours ]morphine consumption in the first 24 hours (including morphine administered in recovery and via PCA).
- Pain Scores [ Time Frame: 1, 6, 12, 24 hours; up to 48 hours postoperative ]Pain scores are recorded at 1, 6, 12, 24 and 48 hours post-operatively, assessed using a visual analog scale (0-100mm) at rest and during 45 degree passive flexion of knee.
- Morphine Consumption [ Time Frame: At 48 hours ]The balance usage after primary outcome
- Postoperative Nausea and Vomiting [ Time Frame: Up to 48 hours ]Presence/absence of nausea and vomiting, and total number of episodes of vomiting
- Sedation Scores [ Time Frame: Up to 48 hours ]
- Quadriceps Strength [ Time Frame: at 24 and 48 hours ]
- Presence of Complications [ Time Frame: up to 48 hours ]Hematoma, wound infection, neurological deficits, any incidence of fall
- Length of Hospital Stay [ Time Frame: Up to 30 days ]Number of days till discharge
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02104934
|Changi General Hospital|
|Principal Investigator:||Yean Chin Lim, MBBS||Changi General Hospital|