Working…
ClinicalTrials.gov
ClinicalTrials.gov Menu
Trial record 77 of 10381 for:    strength

Determination of Muscle Strength in Parkinsonian Patients Through the Use of an Isokinetic Dynamometer (CybexPD001)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02101528
Recruitment Status : Completed
First Posted : April 2, 2014
Last Update Posted : April 2, 2014
Sponsor:
Information provided by (Responsible Party):
Ospedale Generale Di Zona Moriggia-Pelascini

Brief Summary:
Decreased muscle strength has been reported to be a factor contributing to increased incidences of falling in the elderly patients causing fractures, joint dislocations, severe soft tissue lesions and head trauma. Parkinson's Disease (PD) patients often complain of weakness and it has been reported that they have reduced muscle strength, decreased rate of force development, impaired ability to maintain constant force, and increased muscle coactivation during balance perturbation tasks. The specific cause of this weakness is not known, and in this study the investigators have analyzed and measured isokinetic muscle strength in PD patients to clarify this issue. The investigators have compared the data obtained with those of age-matched controls.

Condition or disease
Parkinson's Disease

Detailed Description:

An isokinetic muscle action is defined by its performance at a constant speed or velocity. The laboratory measurements of isokinetic strength provides torque measurements throughout the active range of motion during a maximal effort. Torque is the force rotating about an axis and is produced and recorded from the angular motion. Consequently, the peak torque is an index of the muscular strength. Isokinetic testing was introduced as a quantitative measurement of both statistic and dynamic muscular contraction in which all variables involved (resistance, limb velocity, joint position) are under control. This is because isokinetic muscle testing allows objective, valid, and reliable measurement of the force produced by skeletal muscle during exercise at constant velocity and accommodating resistance and it is appropriate for measuring muscle strength and muscle endurance across the disability spectrum.

Decreased muscle strength has been reported to be a factor contributing to increased incidences of falling in the elderly patients causing fractures, joint dislocations, severe soft tissue lesions and head trauma. Parkinson's Disease (PD) patients often complain of weakness and it has been reported that they have reduced muscle strength, decreased rate of force development, impaired ability to maintain constant force, and increased muscle coactivation during balance perturbation tasks. The specific cause of this weakness is not known, and in this study the investigators have analyzed and measured isokinetic muscle strength in PD patients to clarify this issue. the investigators have compared the data obtained with those of age-matched controls.


Layout table for study information
Study Type : Observational
Actual Enrollment : 40 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Determination of Muscle Strength in Parkinsonian Patients Through the Use of an Isokinetic Dynamometer
Study Start Date : January 2013
Actual Primary Completion Date : December 2013
Actual Study Completion Date : March 2014

Resource links provided by the National Library of Medicine


Group/Cohort
PD Patients
PD patients with a diagnosis of "clinically probable" idiopathic PD in Hoehn-Yahr stage 2-3, with the ability to walk without any assistance, with mini-mental state examination score ≥26, without any relevant comorbidity or vestibular/visual dysfunctions limiting locomotion or balance.
Controls
age and sex matched healthy volunteers



Primary Outcome Measures :
  1. Isokinetic strength [ Time Frame: One month ]
    Laboratory measurements of isokinetic strength


Secondary Outcome Measures :
  1. Muscle functionality [ Time Frame: One month ]

    To establish whether a Intensive Rehabilitation Treatment change the muscle functionality in these patients, and to determine whether isokinetic dynamometry is a reliable method for evaluating muscle strength in patients with PD.

    Muscle strength was measured in lower limbs with the subjects in a sitting position with hip flexed at 90°. To account for the influence of the gravity effect torque, data were corrected by the weight of the subject's lower limb at 45°. Subjects were tested at three fixed angular velocities: 90°/s, 120°/s, 180°/s. The subjects began each isokinetic contraction with the knee flexed at 90° and continued through the full range of motion. Peaks torque were obtained from the maximum isokinetic tests and subsequently analyzed.




Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   55 Years to 79 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Patients diagnosed with PD in stage 2-3 of Hoen&Yahr according to the United Kingdom Brain Bank criteria.

Healthy Volunteers

Criteria

Inclusion Criteria:

  • PD in stage 2-3 of Hoen&Yahr according to the United Kingdom Brain Bank criteria.

Exclusion Criteria:

  • Atypical parkinsonisms
  • PD patients with relevant orthopedic
  • Rheumatic and muscular conditions

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02101528


Locations
Layout table for location information
Italy
Fondazione Salvatore Maugeri
Montescano, Pavia, Italy, 27100
Sponsors and Collaborators
Ospedale Generale Di Zona Moriggia-Pelascini
Investigators
Layout table for investigator information
Principal Investigator: Giuseppe Frazzitta, MD Ospedale Generale di Zona "Moriggia-Pelascini", Gravedona ed Uniti (CO), Italy

Layout table for additonal information
Responsible Party: Ospedale Generale Di Zona Moriggia-Pelascini
ClinicalTrials.gov Identifier: NCT02101528     History of Changes
Other Study ID Numbers: CybexPD001
CybexPD001 ( Other Identifier: Ospedale Generale di Zona "Moriggia-Pelascini" )
First Posted: April 2, 2014    Key Record Dates
Last Update Posted: April 2, 2014
Last Verified: March 2014
Keywords provided by Ospedale Generale Di Zona Moriggia-Pelascini:
Strength in PD patients
Isokinetic muscle strength
Additional relevant MeSH terms:
Layout table for MeSH terms
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases