Diet Induced Intestinal Mucosal Adaptation
|ClinicalTrials.gov Identifier: NCT02088853|
Recruitment Status : Completed
First Posted : March 17, 2014
Last Update Posted : March 21, 2019
|Condition or disease||Intervention/treatment||Phase|
|Healthy Conditions||Dietary Supplement: high fat diet (hfd) Dietary Supplement: high carb diet||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||17 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Small Intestinal Adaptation to Isocaloric Diets Dominated Either by Fats or Carbohydrates|
|Study Start Date :||March 2014|
|Actual Primary Completion Date :||December 2014|
|Actual Study Completion Date :||December 2014|
|Experimental: high fat diet||
Dietary Supplement: high fat diet (hfd)
Sixty % of the energy content is based on fat.
|Active Comparator: high carb diet||
Dietary Supplement: high carb diet
Sixty % of the energy content is based on carbohydrates.
- Mucosal surface enlargement factor [ Time Frame: Appearance after 2 weeks of diet ]The enlargement of the luminal surface area due to the villi structure is a morphometric factor defined as the total area of the mucosal surface in relation to the relatively flat area of the muscular is mucosae.
- Epithelial electrical current in-vitro [ Time Frame: The condition after 2 weeks diet ]Mucosal biopsies are mounted in minUssing chambers. Ion-transporting capacity via SGLT-1 transported is reflected when switching from glucose-free to glucose-containing luminal solution, selectivity of transporter is confirmed by addition of phloridzin.
- Mucosal electrical resistance in vitro [ Time Frame: The condition after 2 weeks diet ]Mucosal biopsies are mounted in miniUssing chambers. Electrical resistance reflecting paracellular permeability is assessed when switching from glucose-free to glucose-containing luminal solution.
- Glycemic control following a test meal [ Time Frame: The condition after 2 weeks diet ]Blood concentrations of glucose and insulin are assessed over 2 hours following a mixed test meal.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02088853
|Dept of Gastrosurgical R&E, Sahlgrenska Universityhospital|
|Gothenburg, Sweden, SE41345|
|Principal Investigator:||Lars Fändriks, MD, PhD||Göteborg University|