Fluid Responsiveness Predicted by PtcO2 in Critically Ill Patients (PtcO2-FR)
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|ClinicalTrials.gov Identifier: NCT02083757|
Recruitment Status : Completed
First Posted : March 11, 2014
Last Update Posted : May 27, 2015
|Condition or disease|
The clinical determination of the intravascular volume can be extremely difficult in critically ill patients. Although hemodynamic maximization was proposed, this approach was associated with a risk of fluid overload and excessive inotropic support. Therefore, fluid optimization was seen as a significant step forward and has been shown to decrease complications. Significant effort has been devoted to defining and developing simple means for predicting fluid responsiveness, i.e. whether the patient will benefit from fluid administration. Passive leg raising (PLR), a bedside performed test, could be used to accurately predict fluid responsiveness in most conditions.
However, most parameters that provide information about fluid responsiveness during volume expansion and PLR are invasive and time-consuming. A completely noninvasive and atraumatic parameter to predict fluid responsiveness might be need urgently. Transcutaneous partial pressure of oxygen (PtcO2), a measure to detect tissue ischemia or inadequate perfusion, might reflect the change in cardiac output, thus predict fluid responsiveness. The purpose of this study was to study the feasibility of predicting fluid responsiveness by transcutaneous partial pressure of oxygen in the critically ill patients.
|Study Type :||Observational|
|Actual Enrollment :||19 participants|
|Official Title:||Fluid Responsiveness Predicted by Transcutaneous Partial Pressure of Oxygen in Critically Ill Patients|
|Study Start Date :||September 2011|
|Actual Primary Completion Date :||April 2014|
|Actual Study Completion Date :||May 2014|
Fluid responsiveness is defined as a change of stroke volume stroke volume ≥ 10% after 250 ml rapid saline infusion in 10 minutes.
Fluid responsiveness is defined as a change of stroke volume stroke volume < 10% after 250 ml rapid saline infusion in 10 minutes.
- Cardiac Output [ Time Frame: 30min ]Noninvasive bioreactance CO monitoring was obtained using the NICOM system (Cheetah Medical, Portland, OR) with four double-electrode stickers placed on the chest wall.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02083757
|Zhongda Hospital Southeast University|
|Nanjing, Jiangsu, China, 210000|