Role of Vitamin C to Augment Iron Chelation With DFP or DFX
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|ClinicalTrials.gov Identifier: NCT02083575|
Recruitment Status : Unknown
Verified March 2014 by Mohsen Saleh Elalfy, Ain Shams University.
Recruitment status was: Not yet recruiting
First Posted : March 11, 2014
Last Update Posted : March 11, 2014
|Condition or disease||Intervention/treatment||Phase|
|Vitamin c Thalassemia Major Iron Chelation||Drug: Vitamin C, Defriprone, deferisarox Drug: deferiprone , deferesarox||Phase 2 Phase 3|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||50 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||Study of Safty and Efficacy of Adjuvant Vitamin c in Augmenting Iron Chelation|
|Study Start Date :||April 2014|
|Estimated Primary Completion Date :||April 2014|
|Estimated Study Completion Date :||April 2014|
Active Comparator: vitamin c
25 heavily iron-loaded thalassemia patients, receiving adjuvant vitamin c with iron chelator.
Drug: Vitamin C, Defriprone, deferisarox
adjuvant vitamin c with iron chelator.
Included 25 heavily iron-loaded thalassemia patients, not receiving adjuvant vitamin c with iron chelator.
Drug: deferiprone , deferesarox
- Vit C to Augment iron chelation [ Time Frame: 12 months ]assess safety and efficacy of Vit C to Augment iron chelation with DFP or DFX in thalassemic patients.
- vitamin c augmenting effect of iron chelator [ Time Frame: 12 month ]better reduction in serum ferritin, LIC and cardiac T28 in group receiving vitamin c
- adverse related events [ Time Frame: 12 month ]safety and occurrence of AEs in both studied groups
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02083575
|Contact: MOHSEN S ELALFY, PROF.||AMIRADIABETES@YAHOO.COM|
|Pediatric Hematology clinic, Ain Shams University Egypt|
|Contact: MOHSEN S ELALFY, PROF AMIRADIABETES@YAHOO.COM|
|Principal Investigator: MOHSEN S ELALFY, PROF|
|Principal Investigator:||MOHSEN S ELALFY, PROF.||Ain Shams University|